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Review
. 2011 Jan;96(1):26-33.
doi: 10.1113/expphysiol.2010.055731. Epub 2010 Nov 5.

Optogenetic probing of functional brain circuitry

James J Mancuso  1 , Jinsook Kim, Soojung Lee, Sachiko Tsuda, Nicholas B H Chow, George J Augustine
Affiliations
Free article
Review

Optogenetic probing of functional brain circuitry

James J Mancuso et al. Exp Physiol. 2011 Jan.
Free article

Abstract

Recently developed optogenetic technologies offer the promise of high-speed mapping of brain circuitry. Genetically targeted light-gated channels and pumps, such as channelrhodopsins and halorhodopsin, allow optical control of neuronal activity with high spatial and temporal resolution. Optogenetic probes of neuronal activity, such as Clomeleon and Mermaid, allow light to be used to monitor the activity of a genetically defined population of neurons. Combining these two complementary sets of optogenetic probes will make it possible to perform all-optical circuit mapping. Owing to the improved efficiency and higher speed of data acquisition, this hybrid approach should enable high-throughput mapping of brain circuitry.

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