Review
doi: 10.1124/mi.10.5.6.
Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy
Affiliations
- PMID: 21045243
- DOI: 10.1124/mi.10.5.6
Item in Clipboard
Review
Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy
Mol Interv.
2010 Oct.
Abstract
Worldwide, more than one billion people are affected by CNS disorders. Despite the huge demand for treatments, existing drugs have limited or no efficacy for some neurological diseases, including brain cancer and certain epilepsies. Furthermore, no effective therapies are available at all for some common disorders of the central nervous system (CNS) such as Alzheimer's disease. ATP-binding cassette (ABC) transporters at the blood-brain barrier (BBB) have become increasingly important in the treatment and pathogenesis of CNS disorders. Here we highlight a novel strategy--targeting signaling pathways that control ABC transporters at the BBB--to protect the brain, improve brain drug delivery, and reduce CNS pathology.
Similar articles
-
Blood-brain barrier active efflux transporters: ATP-binding cassette gene family.NeuroRx. 2005 Jan;2(1):86-98. doi: 10.1602/neurorx.2.1.86. NeuroRx. 2005. PMID: 15717060 Free PMC article. Review.
-
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders.Pharmacol Ther. 2020 Sep;213:107554. doi: 10.1016/j.pharmthera.2020.107554. Epub 2020 Apr 19. Pharmacol Ther. 2020. PMID: 32320731 Review.
-
The ABC of the blood-brain barrier - regulation of drug efflux pumps.Curr Pharm Des. 2011;17(26):2762-70. doi: 10.2174/138161211797440221. Curr Pharm Des. 2011. PMID: 21827407 Review.
-
ABC transporters and drug efflux at the blood-brain barrier.Rev Neurosci. 2010;21(1):29-53. doi: 10.1515/revneuro.2010.21.1.29. Rev Neurosci. 2010. PMID: 20458886 Review.
-
Regulation of ABC transporters blood-brain barrier: the good, the bad, and the ugly.Adv Cancer Res. 2015;125:43-70. doi: 10.1016/bs.acr.2014.10.002. Epub 2015 Jan 8. Adv Cancer Res. 2015. PMID: 25640266 Review.
Cited by
-
Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport.PLoS One. 2019 Nov 27;14(11):e0225702. doi: 10.1371/journal.pone.0225702. eCollection 2019. PLoS One. 2019. PMID: 31774876 Free PMC article.
-
Blood-brain barrier development: Systems modeling and predictive toxicology.Birth Defects Res. 2017 Dec 1;109(20):1680-1710. doi: 10.1002/bdr2.1180. Birth Defects Res. 2017. PMID: 29251840 Free PMC article. Review.
-
Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway.Oxid Med Cell Longev. 2021 Mar 30;2021:6655122. doi: 10.1155/2021/6655122. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33859779 Free PMC article.
-
Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age.Fluids Barriers CNS. 2023 Mar 10;20(1):17. doi: 10.1186/s12987-023-00416-5. Fluids Barriers CNS. 2023. PMID: 36899432 Free PMC article.
-
Na(+) dependent acid-base transporters in the choroid plexus; insights from slc4 and slc9 gene deletion studies.Front Physiol. 2013 Oct 22;4:304. doi: 10.3389/fphys.2013.00304. Front Physiol. 2013. PMID: 24155723 Free PMC article. Review.