Review
doi: 10.3109/10799893.2010.518152.
Epub 2010 Oct 18.
The α1-adrenergic receptors: diversity of signaling networks and regulation
Affiliations
- PMID: 20954794
- PMCID: PMC3018134
- DOI: 10.3109/10799893.2010.518152
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Review
The α1-adrenergic receptors: diversity of signaling networks and regulation
J Recept Signal Transduct Res.
2010 Dec.
Free PMC article
Erratum in
- J Recept Signal Transduct Res. 2011 Aug;31(4):314
Abstract
The α(1)-adrenergic receptor (AR) subtypes (α(1a), α(1b), and α(1d)) mediate several physiological effects of epinephrine and norepinephrine. Despite several studies in recombinant systems and insight from genetically modified mice, our understanding of the physiological relevance and specificity of the α(1)-AR subtypes is still limited. Constitutive activity and receptor oligomerization have emerged as potential features regulating receptor function. Another recent paradigm is that β arrestins and G protein-coupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. The aim of this review is to summarize our current knowledge on some recently identified functional paradigms and signaling networks that might help to elucidate the functional diversity of the α(1)-AR subtypes in various organs.
Figures
The α1-adrenergic receptor subtypes in the cardiovascular system. This figure summarizes the main roles played by distinct α1-AR subtypes in the cardiovascular system highlighted by studies on genetically modified mice.
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