Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1990;68 Suppl(Suppl):9-12.

Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a review of the University of Maryland studies, 1971-75

D F Clyde  1
Affiliations
Review

Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a review of the University of Maryland studies, 1971-75

D F Clyde. Bull World Health Organ. 1990.

Abstract

The immunogenicity in adult male volunteers of sporozoites of Plasmodium falciparum and P. vivax was evaluated at the University of Maryland from 1971 to 1975. Inoculation of large numbers of sporozoites by mosquitos that had been X-irradiated proved safe and well tolerated, and the sporozoites were rendered noninfective. Three volunteers were protectively immunized by this method, one against P. falciparum, one against P. vivax, and one against both species. Protection was species- and stage-specific, but effective against all strains tested within a species, and was reflected by a rise in titre of antibody to the circumsporozoite protein.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Trop Med Hyg. 1975 May;24(3):397-401 - PubMed
    1. Mil Med. 1969 Sep;134(10):1183-90 - PubMed
    1. Nature. 1969 May 3;222(5192):488-9 - PubMed
    1. Am J Med Sci. 1973 Dec;266(6):398-403 - PubMed
    1. Am J Med Sci. 1973 Sep;266(3):169-77 - PubMed

Substances

LinkOut - more resources