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Comment
. 2010 Oct;17(10):1166-7.
doi: 10.1038/nsmb1010-1166.

One motor driving two translocases

Smita S Patel  1
Affiliations
Comment

One motor driving two translocases

Smita S Patel. Nat Struct Mol Biol. 2010 Oct.

Abstract

In this issue, Wu et al. show that the RecBC helicase, which is involved in repairing double-strand DNA breaks,uses one ATPase motor to drive two translocases along opposite strands of DNA—much as an all-wheel drive engine controls movement of both front and back wheels. This mechanism may allow RecBC to load onto blunt-end DNA more efficiently and to move through obstacles such as gaps and DNA damage.

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