Ikaros in immune receptor signaling, lymphocyte differentiation, and function
- PMID: 20888815
- DOI: 10.1016/j.febslet.2010.09.042
Ikaros in immune receptor signaling, lymphocyte differentiation, and function
Abstract
Ikaros is the founding member of a family of transcription factors. Ikaros proteins are required for the normal development of lymphocytes and other blood cell lineages, and have an important role in haematopoietic malignancies. Accumulating data link Ikaros to immune receptor rearrangement and signaling, and the balance between proliferation and differentiation of immune cells. The emerging picture is that Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Similar articles
-
Multiple functions of Ikaros in hematological malignancies, solid tumor and autoimmune diseases.Gene. 2019 Feb 5;684:47-52. doi: 10.1016/j.gene.2018.10.045. Epub 2018 Oct 22. Gene. 2019. PMID: 30352248 Review.
-
Ikaros-family proteins: in search of molecular functions during lymphocyte development.Curr Top Microbiol Immunol. 2005;290:29-47. doi: 10.1007/3-540-26363-2_3. Curr Top Microbiol Immunol. 2005. PMID: 16480038 Review.
-
Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.Int J Mol Sci. 2021 Jan 22;22(3):1103. doi: 10.3390/ijms22031103. Int J Mol Sci. 2021. PMID: 33499314 Free PMC article. Review.
-
The Ikaros family in lymphocyte development.Curr Opin Immunol. 2018 Apr;51:14-23. doi: 10.1016/j.coi.2017.11.005. Epub 2017 Dec 24. Curr Opin Immunol. 2018. PMID: 29278858 Review.
-
The role of the Ikaros gene in lymphocyte development and homeostasis.Annu Rev Immunol. 1997;15:155-76. doi: 10.1146/annurev.immunol.15.1.155. Annu Rev Immunol. 1997. PMID: 9143685 Review.
Cited by
-
Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL.Oncotarget. 2016 Aug 16;7(33):53679-53701. doi: 10.18632/oncotarget.10725. Oncotarget. 2016. PMID: 27447561 Free PMC article.
-
Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo.J Immunol. 2013 Aug 15;191(4):1957-64. doi: 10.4049/jimmunol.1300267. Epub 2013 Jul 15. J Immunol. 2013. PMID: 23858029 Free PMC article.
-
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.Blood. 2013 Oct 10;122(15):2622-9. doi: 10.1182/blood-2012-10-462358. Epub 2013 Aug 23. Blood. 2013. PMID: 23974192 Free PMC article.
-
Differential co-expression-based detection of conditional relationships in transcriptional data: comparative analysis and application to breast cancer.Genome Biol. 2019 Nov 14;20(1):236. doi: 10.1186/s13059-019-1851-8. Genome Biol. 2019. PMID: 31727119 Free PMC article.
-
ATP-dependent chromatin remodeling in T cells.Biochem Cell Biol. 2012 Feb;90(1):1-13. doi: 10.1139/o11-042. Epub 2011 Oct 14. Biochem Cell Biol. 2012. PMID: 21999456 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
