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. 2011 Feb;32(1):189-96.
doi: 10.1007/s13277-010-0112-y. Epub 2010 Sep 24.

Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies

Vilma Oliveira Frick  1 , Claudia Rubie, Pirus Ghadjar, Sabrina K Faust, Mathias Wagner, Stefan Gräber, Martin K Schilling
Affiliations

Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies

Vilma Oliveira Frick et al. Tumour Biol. 2011 Feb.

Abstract

Chemokines have been proposed to contribute to tumour growth and metastatic spread of several cancer entities. Here, we examined the relative levels of CXCL12/CXCR4 in resection specimens from patients with different malignant and non-malignant colorectal diseases as well as colorectal liver metastases (CRLM). CXCL12/CXCR4 mRNA and protein expression profiles were assessed by quantitative real-time PCR, Western blot analysis, enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry in resection specimens from patients with ulcerative colitis (UC; n = 15), colorectal adenoma (CRA; n = 15), colorectal adenocarcinoma (CRC; n = 47) and CRLM (n = 16). Corresponding non-affected tissues served as control. In contrast to UC tissues, CXCL12 showed a distinct down-regulation in CRA, CRC and CRLM specimens, whereas the corresponding receptor CXCR4 demonstrated a significant up-regulation in CRC and CRLM related to corresponding non-affected tissues (p < 0.05, respectively). Our results strongly suggest an association between CXCL12/CXCR4 expression and the induction of CRA, CRC and the development of CRLM. Therefore, CXCR4 may be a potential target for specific therapeutic interventions.

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References

    1. World J Gastroenterol. 2006 Nov 7;12(41):6627-33 - PubMed
    1. Clin Cancer Res. 2000 Sep;6(9):3530-5 - PubMed
    1. Exp Cell Res. 2005 Oct 15;310(1):117-30 - PubMed
    1. World J Gastroenterol. 2008 Aug 14;14(30):4721-4 - PubMed
    1. Int J Colorectal Dis. 2010 Oct;25(10):1185-91 - PubMed

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