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Review
. 2010 Oct;239(10):2522-33.
doi: 10.1002/dvdy.22394.

Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye

Ying-Hsuan Wang  1 , Min-Lang Huang
Affiliations
Free PMC article
Review

Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye

Ying-Hsuan Wang et al. Dev Dyn. 2010 Oct.
Free PMC article

Abstract

The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is one of the main signaling pathways in eukaryotic cells. This pathway is used during diverse growth and developmental processes in multiple tissues to control cell proliferation, differentiation, survival, and apoptosis. In addition to its role during development, the JAK/STAT pathway has also been implicated in tumorigenesis. Drosophila melanogaster is a powerful genetic tool, and its eyes have been used extensively as a platform to study signaling pathways. Many reports have demonstrated that the JAK/STAT pathway plays pleiotropic roles in Drosophila eye development. Its functions and activation are decided by its interplay with other signal pathways and the epigenetic status. In this review, we focus on the functions and regulation of the JAK/STAT pathway during eye development and provide some insights into the study of this pathway in tumorigenesis.

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Figures

Fig. 1
Fig. 1
Schematic diagram of the JAK/STAT pathway in Drosophila. The basic components of the JAK/STAT pathway include the secreted ligand Unpaired (Upd), the transmembrane receptor Domeless (Dome), the JAK Hopscotch (Hop), and the transcription factor STAT92E. The pathway is regulated by multiple signal pathways, chromatin modification, and other regulators. Please refer to the text for details.
Fig. 2
Fig. 2
Functions of the JAK/STAT pathway in Drosophila eye development. The JAK/STAT pathway plays various roles during eye development. This schematic diagram shows the eye disc at different larval stages and the corresponding functions of the JAK/STAT pathway. Details are described in the text. The eye-antennal discs are drawn with anterior to the left and dorsal to the top. Light green, Iro-C expression; Pink, upd expression; yellow lines, dorsal–ventral midline; light blue, Notch/Eyg signaling; dark green, wg expression; gray lines, morphogenetic furrow (MF); gray arrow, MF progression; black and red arrow, ommatidial polarity.
Fig. 3
Fig. 3
Model of the interplay among the JAK/STAT pathway, other signal pathways, and epigenetic status. During development, the JAK/STAT pathway, other signal pathways (such as Notch pathway), and epigenetic status cooperate to influence each other. The interplay determines the activation and functions of the JAK/STAT pathway and, ultimately, developmental events.
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