The use of cell-delivered gene therapy for the treatment of HIV/AIDS

doi:10.1007/s12026-010-8169-7

Review

. 2010 Dec;48(1-3):84-98.

doi: 10.1007/s12026-010-8169-7.

The use of cell-delivered gene therapy for the treatment of HIV/AIDS

Geoff P Symonds¹, Helen A Johnstone, Michelle L Millington, Maureen P Boyd, Bryan P Burke, Louis R Breton

Affiliations

Affiliation

¹ UCLA Department of Microbiology, Immunology and Molecular Genetics, UCLA AIDS Institute, 10940 Wilshire Blvd., Los Angeles, CA 90024-1678, USA. geoff.symonds@calimmuneinc.com

PMID: 20737298
DOI: 10.1007/s12026-010-8169-7

Review

The use of cell-delivered gene therapy for the treatment of HIV/AIDS

Geoff P Symonds et al. Immunol Res. 2010 Dec.

. 2010 Dec;48(1-3):84-98.

doi: 10.1007/s12026-010-8169-7.

Authors

Geoff P Symonds¹, Helen A Johnstone, Michelle L Millington, Maureen P Boyd, Bryan P Burke, Louis R Breton

Affiliation

¹ UCLA Department of Microbiology, Immunology and Molecular Genetics, UCLA AIDS Institute, 10940 Wilshire Blvd., Los Angeles, CA 90024-1678, USA. geoff.symonds@calimmuneinc.com

PMID: 20737298
DOI: 10.1007/s12026-010-8169-7

Abstract

HIV/AIDS is a disease that impairs immune function, primarily by decreasing T-lymphocyte count. Its progression can be contained by highly active antiretroviral therapy (HAART), but there are side effects that can be severe, and the development of resistance often forces the physician to modify the HAART regimen. There are no vaccines available for HIV. An alternative approach that could provide a path to a curative therapy is the use of cell-delivered gene therapy in which an anti-HIV gene(s) is introduced into hematopoietic cells to produce a population that is protected from the effects of HIV. In this paper, we review the field and discuss an approach using a short hairpin RNA to CCR5, an important co-receptor for HIV.

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Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor.
Wolstein O, Boyd M, Millington M, Impey H, Boyer J, Howe A, Delebecque F, Cornetta K, Rothe M, Baum C, Nicolson T, Koldej R, Zhang J, Keech N, Camba Colón J, Breton L, Bartlett J, An DS, Chen IS, Burke B, Symonds GP. Wolstein O, et al. Mol Ther Methods Clin Dev. 2014 Feb 12;1:11. doi: 10.1038/mtm.2013.11. eCollection 2014. Mol Ther Methods Clin Dev. 2014. PMID: 26015947 Free PMC article.
Ex vivo gene therapy for HIV-1 treatment.
Scherer LJ, Rossi JJ. Scherer LJ, et al. Hum Mol Genet. 2011 Apr 15;20(R1):R100-7. doi: 10.1093/hmg/ddr160. Epub 2011 Apr 19. Hum Mol Genet. 2011. PMID: 21505069 Free PMC article. Review.
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A quantitative comparison of anti-HIV gene therapy delivered to hematopoietic stem cells versus CD4+ T cells.
Savkovic B, Nichols J, Birkett D, Applegate T, Ledger S, Symonds G, Murray JM. Savkovic B, et al. PLoS Comput Biol. 2014 Jun 19;10(6):e1003681. doi: 10.1371/journal.pcbi.1003681. eCollection 2014 Jun. PLoS Comput Biol. 2014. PMID: 24945407 Free PMC article.
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Mitsuyasu RT, Zack JA, Macpherson JL, Symonds GP. Mitsuyasu RT, et al. Stem Cells Int. 2011;2011:393698. doi: 10.4061/2011/393698. Epub 2011 Jun 13. Stem Cells Int. 2011. PMID: 21716651 Free PMC article.

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References

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[1] J Virol. 1996 Jul;70(7):4352-60 - PubMed

[2] J Virol. 1996 Jul;70(7):4352-60 - PubMed

[3] Mol Ther. 2000 Mar;1(3):244-54 - PubMed

[4] Mol Ther. 2000 Mar;1(3):244-54 - PubMed

[5] Nat Rev Drug Discov. 2009 Apr;8(4):267 - PubMed

[6] Nat Rev Drug Discov. 2009 Apr;8(4):267 - PubMed

[7] Nat Med. 2002 Jul;8(7):681-6 - PubMed

[8] Nat Med. 2002 Jul;8(7):681-6 - PubMed

[9] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8000-4 - PubMed

[10] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8000-4 - PubMed

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The use of cell-delivered gene therapy for the treatment of HIV/AIDS

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The use of cell-delivered gene therapy for the treatment of HIV/AIDS

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