Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection
- PMID: 20686022
- PMCID: PMC2950560
- DOI: 10.1128/JVI.00856-10
Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection
Abstract
Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8(+) T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8(+) T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8(+) T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required for CD8(+) T cell mononucleosis.
Figures
![FIG. 1.](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd0/2950560/2f1b013a24f3/zjv9990937600001.gif)
![FIG. 2.](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd0/2950560/d678e304ff12/zjv9990937600002.gif)
![FIG. 3.](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd0/2950560/3cb1bde9572e/zjv9990937600003.gif)
![FIG. 4.](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd0/2950560/1915a9ff18bd/zjv9990937600004.gif)
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