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Comment
. 2010 Aug 17;107(33):14519-20.
doi: 10.1073/pnas.1008673107. Epub 2010 Aug 3.

To fold or expand--a charged question

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Comment

To fold or expand--a charged question

Jeremy L England et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic phase diagram for proteins as a function of their net charge and the concentration of the ionic denaturant guanidinium chloride. With increasing denaturant concentrations a folded protein first denatures into a disordered globular phase, which then expands to form a random coil. Many IDPs are already expanded under native conditions because of their high net charge and cannot fold. With increasing guanidinium chloride concentrations, they first incur collapse due to electrostatic screening and then expand again.

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