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. 2010 Aug 2:7:176.
doi: 10.1186/1743-422X-7-176.

Antenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting

Kerina Duri  1 , Felicity Z Gumbo, Knut I Kristiansen, Nyaradzi E Kurewa, Munyaradzi P Mapingure, Simbarashe Rusakaniko, Mike Z Chirenje, Fredrik Muller, Babill Stray-Pedersen
Affiliations

Antenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting

Kerina Duri et al. Virol J. .

Abstract

Objective: To determine HIV-1 RNA load during the third trimester of pregnancy and evaluate its effect on in utero and intra-partum/postpartum transmissions in a breastfeeding population.

Design: A nested case-control study within a PMTCT cohort of antiretroviral therapy naive pregnant women and their infants.

Methods: A case was a mother who transmitted HIV-1 to her infant (transmitter) who was matched to one HIV-1 positive but non-transmitting mother (control).

Results: From a cohort of 691 pregnant women, 177 (25.6%) were HIV-1 positive at enrollment and from these 29 (23%) transmitted HIV-1 to their infants, 10 and 19 during in utero and intra-partum/postpartum respectively. Twenty-four mothers sero-converted after delivery and three transmitted HIV-1 to their infants. Each unit increase in log10 viral load was associated with a 178 cells/mm(3) and 0.2 g/dL decrease in TLC and hemoglobin levels, p = 0.048 and 0.021 respectively, and a 29% increase in the risk of transmission, p = 0.023. Intra-partum/postpartum transmitters had significantly higher mean viral load relative to their matched controls, p = 0.034.

Conclusion: Antenatal serum HIV-1 RNA load, TLC and hemoglobin levels were significantly associated with vertical transmission but this association was independent of transmission time. This finding supports the rationale for preventive strategies designed to reduce vertical transmission by lowering maternal viral load.

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Figures

Figure 1
Figure 1
Summary of the sampling of the 32 transmitters and 32 non-transmitters.
See this image and copyright information in PMC

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References

    1. UNAIDS. Epidemiology Fact Sheet on HIV and AIDS, Zimbabwe, UNAIDS Geneva. 2008.
    1. Brahmbhatt H, Kigozi G, Wabwire-Mangen F, Serwadda D, Lutalo T, Nalugoda F, Sewankambo N, Kiduggavu M, Wawer M, Gray R. Mortality of HIV-1 infected and uninfected children of HIV-1 infected and uninfected mothers in rural Uganda. J Acquir Immun Defic Syndrome. 2006;41(Suppl 4):504–508. doi: 10.1097/01.qai.0000188122.15493.0a. - DOI - PubMed
    1. Mbizvo EM, Msuya SE, Stray-Pedersen B, Sundby J, Chirenje MZ, Hussain A. HIV sero-prevalence and its association with the other reproductive tract infections in asymptomatic women in Harare, Zimbabwe. International Journal of STD and AIDS. 2001;12:524–531. doi: 10.1258/0956462011923624. - DOI - PubMed
    1. Gregson S, Gonese E, Hallet TB, Taruberekera N, Hargrove JW, Lopman B, Corbett EL, Dorrington R, Dube S, Dehne K, Mugurungi O. HIV decline due to reduction in risky sex? Evidence from a comprehensive epidemiological review. Int J Epidemiol. 2010. in press . - PMC - PubMed
    1. Kourtis AP, Bulterys M, Nesheim SR Lee FK. Understanding the timing of HIV transmission from mother to infant. JAMA. 2001;285:709–712. doi: 10.1001/jama.285.6.709. - DOI - PubMed

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