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Review
. 2010 Oct-Nov;52(1-2):102-7.
doi: 10.1016/j.cyto.2010.06.011. Epub 2010 Jul 22.

Interleukin-12 as an adjuvant for induction of protective antibody responses

Dennis W Metzger  1
Affiliations
Review

Interleukin-12 as an adjuvant for induction of protective antibody responses

Dennis W Metzger. Cytokine. 2010 Oct-Nov.

Abstract

Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review.

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Figures

Figure 1
Figure 1. A model for the actions of IL-12 on humoral immunity
IL-12 induces Th1 and NK cells to secrete large amounts of IFN-γ which then causes B cells to switch to γ2a production. Secondarily, IL-12 binds to receptors expressed on plasmablasts and enhances production of the switched isotypes.
See this image and copyright information in PMC

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