Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Oct;15(7):1057-63.
doi: 10.1111/j.1440-1843.2010.01814.x. Epub 2010 Jul 20.

Pneumococci: immunology of the innate host response

Gavin K Paterson  1 , Carlos J Orihuela
Affiliations
Review

Pneumococci: immunology of the innate host response

Gavin K Paterson et al. Respirology. 2010 Oct.

Abstract

Despite the development of vaccines and antibiotics, Streptococcus pneumoniae (the pneumococcus) continues to be a major cause of human morbidity and mortality throughout the world. In recent years our understanding of how the host innate immune system recognizes and responds to pneumococcal infection has advanced significantly. Herein, we highlight some of the key features of the innate response to the pneumococcus.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: C. J. O. has received funding for research unrelated to this review from Novartis Pharmaceuticals.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. O’Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet. 2009;374:893–902. - PubMed
    1. Lynch JP, Zhanel GG. Streptococcus pneumoniae: Epidemiology, Risk Factors, and Strategies for Prevention. Seminars in Respiratory and Critical Care Medicine. 2009;30:189–209. - PubMed
    1. Malley R. Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development. J Mol Med. 2010;88:135–42. - PubMed
    1. Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, et al. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proceedings of the National Academy of Sciences of the United States of America. 2002;99:16969–74. - PMC - PubMed
    1. Yuste J, Botto M, Bottoms SE, Brown JS. Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae. Plos Pathogens. 2007;3:1208–19. - PMC - PubMed

Publication types