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. 2010:2010:425939.
doi: 10.1155/2010/425939. Epub 2010 Jun 10.

Identification of microRNAs involved in the host response to enterovirus 71 infection by a deep sequencing approach

Lunbiao Cui  1 , Xiling Guo, Yuhua Qi, Xian Qi, Yiyue Ge, Zhiyang Shi, Tao Wu, Jun Shan, Yunfeng Shan, Zheng Zhu, Hua Wang
Affiliations

Identification of microRNAs involved in the host response to enterovirus 71 infection by a deep sequencing approach

Lunbiao Cui et al. J Biomed Biotechnol. 2010.

Abstract

Role of microRNA (miRNA) has been highlighted in pathogen-host interactions recently. To identify cellular miRNAs involved in the host response to enterovirus 71 (EV71) infection, we performed a comprehensive miRNA profiling in EV71-infected Hep2 cells through deep sequencing. 64 miRNAs were found whose expression levels changed for more than 2-fold in response to EV71 infection. Gene ontology analysis revealed that many of these mRNAs play roles in neurological process, immune response, and cell death pathways, which are known to be associated with the extreme virulence of EV71. To our knowledge, this is the first study on host miRNAs expression alteration response to EV71 infection. Our findings supported the hypothesis that certain miRNAs might be essential in the host-pathogen interactions.

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Figures

Figure 1
Figure 1
Size distribution of sequenced short RNAs.
Figure 2
Figure 2
Predicted targets gene ontology terms in the biological process category.
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References

    1. McMinn P, Stratov I, Nagarajan L, Davis S. Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia. Clinical Infectious Diseases. 2001;32(2):236–242. - PubMed
    1. Portolani M, Bartoletti AM, Pietrosemoli P, et al. Non-specific febrile illness by Coxsackievirus A16 in a 6-day-old newbornMalattia febbrile aspecifica da Coxackievirus A16 in un neonato di 6 giorni. Minerva Pediatrica. 2004;56(3):341–347. - PubMed
    1. Chang L-Y, Huang L-M, Gau SS-F, et al. Neurodevelopment and cognition in children after enterovirus 71 infection. The New England Journal of Medicine. 2007;356(12):1226–1234. - PubMed
    1. Huang C-C, Liu C-C, Chang Y-C, Chen C-Y, Wang S-T, Yeh T-F. Neurologic complications in children with enterovirus 71 infection. The New England Journal of Medicine. 1999;341(13):936–942. - PubMed
    1. Chang L-Y, Lin T-Y, Huang Y-C, et al. Comparison of enterovirus 71 and coxsackievirus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998. Pediatric Infectious Disease Journal. 1999;18(12):1092–1096. - PubMed

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