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Editorial
. 2010 Jun 17:18:34.
doi: 10.1186/1757-7241-18-34.

"Metabolic staging" after major trauma - a guide for clinical decision making?

Philip F Stahel  1 , Michael A Flierl, Ernest E Moore
Affiliations
Editorial

"Metabolic staging" after major trauma - a guide for clinical decision making?

Philip F Stahel et al. Scand J Trauma Resusc Emerg Med. .

Abstract

Metabolic changes after major trauma have a complex underlying pathophysiology. The early posttraumatic stress response is associated with a state of hyperinflammation, with increased oxygen consumption and energy expenditure. This hypercatabolic state must be recognized early and mandates an early nutritional management strategy. A proactive concept of early enteral "immunonutrition" in severely injured patients, is aimed at counterbalancing the negative aspects of hyperinflammation and hypercatabolism in order to reduce the risk of late complications, including infections and posttraumatic organ failure. Recently, the concept of "metabolic staging" has been advocated, which takes into account the distinct inflammatory phases and metabolic phenotypes after major trauma, including the "ischemia/reperfusion phenotype", the "leukocytic phenotype", and the "angiogenic phenotype". The potential clinical impact of metabolic staging, and of an appropriately adapted "metabolic control" and nutritional support, remains to be determined.

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Figures

Figure 1
Figure 1
Simplified schematic representing the current understanding of the pathophysiological reactions to major trauma, which lead to secondary remote organ dysfunction. (Abbreviations: TLR, Toll-like receptor; DAMPs, damage-associated molecular patterns.)
See this image and copyright information in PMC

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