Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
- PMID: 20541813
- DOI: 10.1016/j.tins.2010.05.001
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
Abstract
In the past decades, a range of post-translational modifications has been discovered on tubulins, the major constituents of microtubules. Pioneering studies have described the occurrence and dynamics of these modifications and provided first insights into their potential functions in regulating the microtubule cytoskeleton. By contrast, several tubulin-modifying enzymes were only discovered in the last few years, and studies on molecular mechanisms and cellular functions of tubulin modifications are just beginning to emerge. This review highlights the roles of tubulin modifications in neurons. Recent studies are also discussed in relation to how the combinatorial use of tubulin modifications could generate a dynamic microtubule code, and how such a code might regulate basic as well as higher-order neuronal functions.
Copyright 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Post-translational modifications of tubulin.Curr Biol. 2014 May 5;24(9):R351-4. doi: 10.1016/j.cub.2014.03.032. Curr Biol. 2014. PMID: 24801181
-
[Microtubules: functional polymorphisms of tubulin and associated proteins (structural and motor MAP's)].C R Seances Soc Biol Fil. 1996;190(2-3):255-68. C R Seances Soc Biol Fil. 1996. PMID: 8869236 Review. French.
-
The tubulin code and its role in controlling microtubule properties and functions.Nat Rev Mol Cell Biol. 2020 Jun;21(6):307-326. doi: 10.1038/s41580-020-0214-3. Epub 2020 Feb 27. Nat Rev Mol Cell Biol. 2020. PMID: 32107477 Review.
-
Accumulation and post-translational modifications of plant tubulins.Plant Biol (Stuttg). 2014 May;16(3):521-7. doi: 10.1111/plb.12104. Epub 2013 Sep 20. Plant Biol (Stuttg). 2014. PMID: 24112714 Review.
-
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions.Nat Rev Mol Cell Biol. 2011 Nov 16;12(12):773-86. doi: 10.1038/nrm3227. Nat Rev Mol Cell Biol. 2011. PMID: 22086369 Review.
Cited by
-
Localization of axonal motor molecules machinery in neurodegenerative disorders.Int J Mol Sci. 2012;13(4):5195-5206. doi: 10.3390/ijms13045195. Epub 2012 Apr 24. Int J Mol Sci. 2012. PMID: 22606038 Free PMC article. Review.
-
The effect of electric stimulation of various frequencies and durations on microtubules in frog motor axon terminals.Dokl Biol Sci. 2014 Nov;459:334-7. doi: 10.1134/S0012496614060076. Epub 2015 Jan 6. Dokl Biol Sci. 2014. PMID: 25560209 No abstract available.
-
DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release.Int J Mol Sci. 2019 Dec 20;21(1):60. doi: 10.3390/ijms21010060. Int J Mol Sci. 2019. PMID: 31861806 Free PMC article.
-
TRIM3 regulates the motility of the kinesin motor protein KIF21B.PLoS One. 2013 Sep 24;8(9):e75603. doi: 10.1371/journal.pone.0075603. eCollection 2013. PLoS One. 2013. PMID: 24086586 Free PMC article.
-
A conceptual view at microtubule plus end dynamics in neuronal axons.Brain Res Bull. 2016 Sep;126(Pt 3):226-237. doi: 10.1016/j.brainresbull.2016.08.006. Epub 2016 Aug 12. Brain Res Bull. 2016. PMID: 27530065 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
