Involvement of members of the cadherin superfamily in cancer
- PMID: 20457567
- PMCID: PMC2882122
- DOI: 10.1101/cshperspect.a003129
Involvement of members of the cadherin superfamily in cancer
Abstract
We review the role of cadherins and cadherin-related proteins in human cancer. Cellular and animal models for human cancer are also dealt with whenever appropriate. E-cadherin is the prototype of the large cadherin superfamily and is renowned for its potent malignancy suppressing activity. Different mechanisms for inactivating E-cadherin/CDH1 have been identified in human cancers: inherited and somatic mutations, aberrant protein processing, increased promoter methylation, and induction of transcriptional repressors such as Snail and ZEB family members. The latter induce epithelial mesenchymal transition, which is also associated with induction of "mesenchymal" cadherins, a hallmark of tumor progression. VE-cadherin/CDH5 plays a role in tumor-associated angiogenesis. The atypical T-cadherin/CDH13 is often silenced in cancer cells but up-regulated in tumor vasculature. The review also covers the status of protocadherins and several other cadherin-related molecules in human cancer. Perspectives for emerging cadherin-related anticancer therapies are given.
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References
-
- Adachi Y, Takeuchi T, Sonobe H, Ohtsuki Y 2006. An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: Possible cross talk between T-cadherin and FGF-2 pathways. Virchows Archiv 448:311–318 - PubMed
-
- Alpaugh ML, Tomlinson JS, Shao ZM, Barsky SH 1999. A novel human xenograft model of inflammatory breast cancer. Cancer Res 59:5079–5084 - PubMed
-
- Anders J, Kjaer S, Ibanez CF 2001. Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. J Biol Chem 276:35808–35817 - PubMed
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