Optimal vaccine stockpile design for an eradicated disease: application to polio
- PMID: 20430122
- DOI: 10.1016/j.vaccine.2010.04.001
Optimal vaccine stockpile design for an eradicated disease: application to polio
Abstract
Eradication of a disease promises significant health and financial benefits. Preserving those benefits, hopefully in perpetuity, requires preparing for the possibility that the causal agent could re-emerge (unintentionally or intentionally). In the case of a vaccine-preventable disease, creation and planning for the use of a vaccine stockpile becomes a primary concern. Doing so requires consideration of the dynamics at different levels, including the stockpile supply chain and transmission of the causal agent. This paper develops a mathematical framework for determining the optimal management of a vaccine stockpile over time. We apply the framework to the polio vaccine stockpile for the post-eradication era and present examples of solutions to one possible framing of the optimization problem. We use the framework to discuss issues relevant to the development and use of the polio vaccine stockpile, including capacity constraints, production and filling delays, risks associated with the stockpile, dynamics and uncertainty of vaccine needs, issues of funding, location, and serotype dependent behavior, and the implications of likely changes over time that might occur. This framework serves as a helpful context for discussions and analyses related to the process of designing and maintaining a stockpile for an eradicated disease.
(c) 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Risk management in a polio-free world.Risk Anal. 2006 Dec;26(6):1441-8. doi: 10.1111/j.1539-6924.2006.00840.x. Risk Anal. 2006. PMID: 17184391 Review.
-
Decision analysis in planning for a polio outbreak in the United States.Pediatrics. 2006 Aug;118(2):611-8. doi: 10.1542/peds.2005-2358. Pediatrics. 2006. PMID: 16882814
-
Polio control after certification: major issues outstanding.Bull World Health Organ. 2004 Jan;82(1):47-52. Epub 2004 Feb 26. Bull World Health Organ. 2004. PMID: 15106300 Free PMC article.
-
Characterization of outbreak response strategies and potential vaccine stockpile needs for the polio endgame.BMC Infect Dis. 2016 Mar 24;16:137. doi: 10.1186/s12879-016-1465-7. BMC Infect Dis. 2016. PMID: 27009272 Free PMC article.
-
Poliovirus vaccination during the endgame: insights from integrated modeling.Expert Rev Vaccines. 2017 Jun;16(6):577-586. doi: 10.1080/14760584.2017.1322514. Epub 2017 May 9. Expert Rev Vaccines. 2017. PMID: 28437234 Review.
Cited by
-
Outbreak response strategies with type 2-containing oral poliovirus vaccines.Vaccine. 2023 Apr 6;41 Suppl 1(Suppl 1):A142-A152. doi: 10.1016/j.vaccine.2022.10.060. Epub 2022 Nov 17. Vaccine. 2023. PMID: 36402659 Free PMC article.
-
Collaboration-competition dilemma in flattening the COVID-19 curve.Prod Oper Manag. 2022 Apr 14:10.1111/poms.13709. doi: 10.1111/poms.13709. Online ahead of print. Prod Oper Manag. 2022. PMID: 35601840 Free PMC article.
-
Using integrated modeling to support the global eradication of vaccine-preventable diseases.Syst Dyn Rev. 2018 Jun;34(1-2):78-120. doi: 10.1002/sdr.1589. Syst Dyn Rev. 2018. PMID: 34552305 Free PMC article.
-
Advancing sustainable development goals through immunization: a literature review.Global Health. 2021 Aug 26;17(1):95. doi: 10.1186/s12992-021-00745-w. Global Health. 2021. PMID: 34446050 Free PMC article. Review.
-
Serotype 2 oral poliovirus vaccine (OPV2) choices and the consequences of delaying outbreak response.Vaccine. 2023 Apr 6;41 Suppl 1(Suppl 1):A136-A141. doi: 10.1016/j.vaccine.2021.04.061. Epub 2021 May 14. Vaccine. 2023. PMID: 33994237 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical