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Review
. 2010 Jun;11(6):426-37.
doi: 10.1038/nrg2781. Epub 2010 Apr 27.

Inducible gene expression: diverse regulatory mechanisms

Vikki M Weake  1 , Jerry L Workman
Affiliations
Review

Inducible gene expression: diverse regulatory mechanisms

Vikki M Weake et al. Nat Rev Genet. 2010 Jun.

Abstract

The rapid activation of gene expression in response to stimuli occurs largely through the regulation of RNA polymerase II-dependent transcription. In this Review, we discuss events that occur during the transcription cycle in eukaryotes that are important for the rapid and specific activation of gene expression in response to external stimuli. In addition to regulated recruitment of the transcription machinery to the promoter, it has now been shown that control steps can include chromatin remodelling and the release of paused polymerase. Recent work suggests that some components of signal transduction cascades also play an integral part in activating transcription at target genes.

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References

    1. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13887-91 - PubMed
    1. Eukaryot Cell. 2006 Oct;5(10):1738-47 - PubMed
    1. Nature. 1988 Apr 28;332(6167):853-6 - PubMed
    1. Mol Cell Biol. 1999 Dec;19(12):8136-45 - PubMed
    1. Genes Dev. 2003 Feb 15;17(4):502-15 - PubMed

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