Adaptin' endosomes for synaptic vesicle recycling, learning and memory

doi:10.1038/emboj.2010.47

Comment

. 2010 Apr 21;29(8):1313-5.

doi: 10.1038/emboj.2010.47.

Adaptin' endosomes for synaptic vesicle recycling, learning and memory

Michael Krauss¹, Volker Haucke

Affiliations

PMID: 20407473
PMCID: PMC2868580
DOI: 10.1038/emboj.2010.47

Comment

Adaptin' endosomes for synaptic vesicle recycling, learning and memory

Michael Krauss et al. EMBO J. 2010.

. 2010 Apr 21;29(8):1313-5.

doi: 10.1038/emboj.2010.47.

Authors

Michael Krauss¹, Volker Haucke

Affiliation

¹ Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität & Charite Universitätsmedizin Berlin, Berlin, Germany.

PMID: 20407473
PMCID: PMC2868580
DOI: 10.1038/emboj.2010.47

No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

**Figure 1**
Hypothetical model for the role of different clathrin/AP complexes in SV recycling. (A) SVs are clustered near the active zone (AZ). (B) In wild type SVs are recycled mainly by CME. Sustained high-level activity induces BE involving formation of vacuoles. Fission likely involves dynamin (red circles). SV reformation from vacuoles occurs, at least in part, by clathrin-dependent budding. (C) Nerve terminals of AP-1/σ1B-KO mice display reduced numbers of SVs. Clathrin-coated buds accumulate on vacuoles that might have originated from BE. Buds may contain AP-1/σ1A, AP-2, or AP-3.

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Comment on

AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.
Glyvuk N, Tsytsyura Y, Geumann C, D'Hooge R, Hüve J, Kratzke M, Baltes J, Boening D, Klingauf J, Schu P. Glyvuk N, et al. EMBO J. 2010 Apr 21;29(8):1318-30. doi: 10.1038/emboj.2010.15. Epub 2010 Mar 4. EMBO J. 2010. PMID: 20203623 Free PMC article.

Cited by

Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.
Haucke V, Neher E, Sigrist SJ. Haucke V, et al. Nat Rev Neurosci. 2011 Mar;12(3):127-38. doi: 10.1038/nrn2948. Epub 2011 Feb 9. Nat Rev Neurosci. 2011. PMID: 21304549 Review.
Endosomal sorting of readily releasable synaptic vesicles.
Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO. Hoopmann P, et al. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19055-60. doi: 10.1073/pnas.1007037107. Epub 2010 Oct 18. Proc Natl Acad Sci U S A. 2010. PMID: 20956291 Free PMC article.

References

1. Glyvuk N, Tsytsyura Y, Geumann C, D'Hooge R, Hüve J, Kratzke M, Baltes J, Böning D, Klingauf J, Schu P (2010) AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J 29: 1318–1330 - PMC - PubMed
1. Heerssen H, Fetter RD, Davis GW (2008) Clathrin dependence of synaptic-vesicle formation at the Drosophila neuromuscular junction. Curr Biol 18: 401–409 - PMC - PubMed
1. Kasprowicz J, Kuenen S, Miskiewicz K, Habets RL, Smitz L, Verstreken P (2008) Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. J Cell Biol 182: 1007–1016 - PMC - PubMed
1. Kim SH, Ryan TA (2009) Synaptic vesicle recycling at CNS snapses without AP-2. J Neurosci 29: 3865–3874 - PMC - PubMed
1. Murthy VN, De Camilli P (2003) Cell biology of the presynaptic terminal. Annu Rev Neurosci 26: 701–728 - PubMed

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[1] Glyvuk N, Tsytsyura Y, Geumann C, D'Hooge R, Hüve J, Kratzke M, Baltes J, Böning D, Klingauf J, Schu P (2010) AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J 29: 1318–1330 - PMC - PubMed

[2] Glyvuk N, Tsytsyura Y, Geumann C, D'Hooge R, Hüve J, Kratzke M, Baltes J, Böning D, Klingauf J, Schu P (2010) AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J 29: 1318–1330 - PMC - PubMed

[3] Heerssen H, Fetter RD, Davis GW (2008) Clathrin dependence of synaptic-vesicle formation at the Drosophila neuromuscular junction. Curr Biol 18: 401–409 - PMC - PubMed

[4] Heerssen H, Fetter RD, Davis GW (2008) Clathrin dependence of synaptic-vesicle formation at the Drosophila neuromuscular junction. Curr Biol 18: 401–409 - PMC - PubMed

[5] Kasprowicz J, Kuenen S, Miskiewicz K, Habets RL, Smitz L, Verstreken P (2008) Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. J Cell Biol 182: 1007–1016 - PMC - PubMed

[6] Kasprowicz J, Kuenen S, Miskiewicz K, Habets RL, Smitz L, Verstreken P (2008) Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. J Cell Biol 182: 1007–1016 - PMC - PubMed

[7] Kim SH, Ryan TA (2009) Synaptic vesicle recycling at CNS snapses without AP-2. J Neurosci 29: 3865–3874 - PMC - PubMed

[8] Kim SH, Ryan TA (2009) Synaptic vesicle recycling at CNS snapses without AP-2. J Neurosci 29: 3865–3874 - PMC - PubMed

[9] Murthy VN, De Camilli P (2003) Cell biology of the presynaptic terminal. Annu Rev Neurosci 26: 701–728 - PubMed

[10] Murthy VN, De Camilli P (2003) Cell biology of the presynaptic terminal. Annu Rev Neurosci 26: 701–728 - PubMed

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Adaptin' endosomes for synaptic vesicle recycling, learning and memory

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Adaptin' endosomes for synaptic vesicle recycling, learning and memory

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