A role for codon order in translation dynamics
- PMID: 20403329
- DOI: 10.1016/j.cell.2010.02.036
A role for codon order in translation dynamics
Erratum in
- Cell. 2010 May 14;141(4):728. Cannarrozzi, Gina [corrected to Cannarozzi, Gina]
Abstract
The genetic code is degenerate. Each amino acid is encoded by up to six synonymous codons; the choice between these codons influences gene expression. Here, we show that in coding sequences, once a particular codon has been used, subsequent occurrences of the same amino acid do not use codons randomly, but favor codons that use the same tRNA. The effect is pronounced in rapidly induced genes, involves both frequent and rare codons and diminishes only slowly as a function of the distance between subsequent synonymous codons. Furthermore, we found that in S. cerevisiae codon correlation accelerates translation relative to the translation of synonymous yet anticorrelated sequences. The data suggest that tRNA diffusion away from the ribosome is slower than translation, and that some tRNA channeling takes place at the ribosome. They also establish that the dynamics of translation leave a significant signature at the level of the genome.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment in
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How the sequence of a gene can tune its translation.Cell. 2010 Apr 16;141(2):227-9. doi: 10.1016/j.cell.2010.03.033. Cell. 2010. PMID: 20403320 Free PMC article. Review.
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