The role of apoptosis proteins and complement components in the etiopathogenesis of systemic lupus erythematosus
- PMID: 20360925
- PMCID: PMC2845775
- DOI: 10.1590/S1807-59322010000300014
The role of apoptosis proteins and complement components in the etiopathogenesis of systemic lupus erythematosus
Abstract
Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is a consensus that accelerated apoptosis of circulating lymphocytes and/or impaired clearance of apoptotic bodies may increase the amount of nuclear antigens presented to T lymphocytes. This process is accompanied by autoimmune responses that can lead to the development of lupus. The dysfunction of apoptosis may be a direct consequence of alterations in proteins/genes such as Fas, Bcl-2 and C1q. Increased expression of Fas antigen could intensify the exposure of hidden antigens. The overexpression of Bcl-2 protein might inhibit the removal of auto-reactive cells, and the lack of C1q could impair the clearance of self-antigens. The complete knowledge of the role of apoptosis components in the etiopathogenesis of lupus could lead to the development of new therapies targeting the apoptotic threshold, which could result in a more specific and effective disease response compared to global immunosuppression. This review summarizes the role of each component of the apoptotic process in the pathogenesis of lupus.
Keywords: Apoptosis; Bcl-2 protein; C1q complement component; Fas protein; Systemic Lupus Erythematosus.
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References
-
- Andrade F, Casciola-Rosen L, Rosen A. Apoptosis in Systemic Lupus Erythematosus. Clinical Implications. Rheum Dis Clin of North Am. 2000;26:215–27. - PubMed
-
- Munoz LE, van Bavel C, Franz S, Berden J, Herrmann M, van der Vlag J. Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus. 2008;17:371–5. - PubMed
-
- Rahman A, Iseberg DA. Mechanisms of Disease. Systemic Lupus Erythematosus. N Engl J Med. 2008;358:929–39. - PubMed
-
- Kamradt T, Mitchinson NA. Advances in immunology: Tolerance and Autoimmunity. N Engl J Med. 2001;344:655–64. - PubMed
-
- Green DR. Overview: apoptotic signaling pathways in the immune system. Immunological Reviews. 2003;193:5–9. - PubMed
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