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Review
. 2010 Jul;30(4):491-5.
doi: 10.1007/s10875-010-9384-7. Epub 2010 Mar 31.

Exposing viruses: RNA patterns sensed by RIG-I-like receptors

Jan Rehwinkel  1
Affiliations
Review

Exposing viruses: RNA patterns sensed by RIG-I-like receptors

Jan Rehwinkel. J Clin Immunol. 2010 Jul.

Abstract

Introduction: Virus infection triggers a multitude of innate immune pathways that limit viral replication, restrict viral spread and coordinate antigen-specific, adaptive immune responses. Type-I interferons (IFNs) play a crucial role in these events. Innate receptors expressed by the host cell recognize virus presence and signal for rapid IFN induction following infection.

Scope: This review article discusses recent progress in our understanding of how cytoplasmic RIG-I-like receptors detect infection with RNA viruses.

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