Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Feb;30(2):463-6.

Ultrasound-enhanced microfluidic synthesis of liposomes

Xiaomeng Huang  1 , Ryan Caddell, Bo Yu, Songlin Xu, Brittany Theobald, L James Lee, Robert J Lee
Affiliations

Ultrasound-enhanced microfluidic synthesis of liposomes

Xiaomeng Huang et al. Anticancer Res. 2010 Feb.

Abstract

Background: Liposomes have been successfully used as delivery vehicles for anticancer drugs. Both sonication and microfluidic technologies have been used to produce liposomes. The combination of the two methods was evaluated in this study.

Materials and methods: The microfluidic devices, mainly comprising micro-dispensers and a sonicator, were used to produce liposomal nanoparticles. Sonication was used to enhance the reduction of liposome size.

Results: Sonication significantly reduced the size of the liposomes. The particle size also decreased as the buffer to solvent flow rate ratio increased. The smallest particle sizes were achieved with a volumetric flow rate of lipids at 0.374 ml/min.

Conclusion: The microfluidic devices in combination with ultrasound are simple and may be used to produce liposomal nanoparticles with narrow size distribution.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Photographs of the microfluidic device with a bath sonicator for production of liposomes. A, top view; B, side view.
Figure 2
Figure 2
Photographs of the microfluidic chip with 3 inlets and 1 outlet.
Figure 3
Figure 3
Flow rate ratio versus particle size of liposomes synthesized in microfluidics with or without sonication.
Figure 4
Figure 4
Flow rates versus particle size of liposomes prepared in microfluidics with or without sonication.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gregoriadis G. Liposome Technology. New York: Taylor & Francis/Informa; 2006.
    1. Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov. 2005;4(2):145–160. - PubMed
    1. Fenske DB, Cullis PR. Liposomal nanomedicines. Expert Opin Drug Deliv. 2008;5(1):25–44. - PubMed
    1. Abraham SA, Waterhouse DN, Mayer LD, Cullis PR, Madden TD, Bally MB. The liposomal formulation of doxorubicin. Methods Enzymol. 2005;391:71–97. - PubMed
    1. Pan XQ, Lee RJ. In vivo antitumor activity of folate receptor-targeted liposomal daunorubicin in a murine leukemia model. Anticancer Res. 2005;25(1A):343–346. - PubMed

Publication types

LinkOut - more resources