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Review
. 2010 Mar 19;140(6):805-20.
doi: 10.1016/j.cell.2010.01.022.

Pattern recognition receptors and inflammation

Osamu Takeuchi  1 , Shizuo Akira
Affiliations
Free article
Review

Pattern recognition receptors and inflammation

Osamu Takeuchi et al. Cell. .
Free article

Abstract

Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors. The intracellular signaling cascades triggered by these PRRs lead to transcriptional expression of inflammatory mediators that coordinate the elimination of pathogens and infected cells. However, aberrant activation of this system leads to immunodeficiency, septic shock, or induction of autoimmunity. In this Review, we discuss the role of PRRs, their signaling pathways, and how they control inflammatory responses.

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