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. 2010 Feb 23;28(8):1924-31.
doi: 10.1016/j.vaccine.2009.10.100.

Viral reservoir is suppressed but not eliminated by CD8 vaccine specific lymphocytes

Jiangmei Yin  1 , Anlan Dai, Anding Shen, Jonathan Lecureux, Mark G Lewis, Jean D Boyer
Affiliations

Viral reservoir is suppressed but not eliminated by CD8 vaccine specific lymphocytes

Jiangmei Yin et al. Vaccine. .

Abstract

It has long been postulated that while CD8 lymphocytes are capable of suppressing human immunodeficiency virus (HIV)-1 replication it is unlikely that the viral reservoirs once formed can be cleared. Our previous studies demonstrate that co-immunizing cynomologous macaques with a simian/human immunodeficiency virus (SHIV) DNA-based vaccines induces a strong cellular immune response that is able to suppress viral replication. We further demonstrated that interleukin (IL)-12 could significantly enhance the vaccine specific CD8 lymphocyte response. In this manuscript cynomologous macaques were vaccinated with a SHIV DNA-based vaccine co-delivered with IL-12. The macaques were then challenged with SHIV89.6p. Two years post-immunization and viral challenge we transiently depleted CD8(+) T cells. Plasma viral load increased, demonstrating the central role of CD8(+) T cells in viral suppression yet an inability to clear the viral reservoirs. Furthermore, in the data presented here, we found a higher number of IFN-gamma producing vaccine specific cells did not enhance suppression of viral replication.

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