Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Feb 22;188(4):451-2.
doi: 10.1083/jcb.201001121. Epub 2010 Feb 15.

Unconventional secretion by autophagosome exocytosis

Suzanne R Pfeffer  1
Affiliations
Comment

Unconventional secretion by autophagosome exocytosis

Suzanne R Pfeffer. J Cell Biol. .

Abstract

In this issue, Duran et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911154) and Manjithaya et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911149) use yeast genetics to reveal a role for autophagosome intermediates in the unconventional secretion of an acyl coenzyme A (CoA)-binding protein that lacks an endoplasmic reticulum signal sequence. Medium-chain acyl CoAs are also required and may be important for substrate routing to this pathway.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
A model for unconventional secretion of Acb1. Selective autophagy involves cargo collection on the surface of a phagophore membrane (blue). These are engulfed by a multivesicular endosome that fuses with the plasma membrane to release its content. Whether the phagophore is released from an endosomal, lumenal vesicle by lipase action before exocytosis (?) is not known. Duran et al. (2010) and Manjithaya et al. (2010) show that the t-SNARE Sso1 is needed for exocytosis, and fusion with the vacuole is not required.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Anjard C., Zeng C., Loomis W.F., Nellen W. 1998. Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum. Dev. Biol. 193:146–155 10.1006/dbio.1997.8804 - DOI - PubMed
    1. Duran J.M., Anjard C., Stefan C., Loomis W.F., Malhotra V. 2010. Unconventional secretion of Acb1 is mediated by autophagosomes. J. Cell Biol. 188:527–536 - PMC - PubMed
    1. Itoh T., Fujita N., Kanno E., Yamamoto A., Yoshimori T., Fukuda M. 2008. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol. Biol. Cell. 19:2916–2925 10.1091/mbc.E07-12-1231 - DOI - PMC - PubMed
    1. Keller M., Rüegg A., Werner S., Beer H.D. 2008. Active caspase-1 is a regulator of unconventional protein secretion. Cell. 132:818–831 10.1016/j.cell.2007.12.040 - DOI - PubMed
    1. Kinseth M.A., Anjard C., Fuller D., Guizzunti G., Loomis W.F., Malhotra V. 2007. The Golgi-associated protein GRASP is required for unconventional protein secretion during development. Cell. 130:524–534 10.1016/j.cell.2007.06.029 - DOI - PubMed

Substances