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. 2010 Jan 28;16(4):479-83.
doi: 10.3748/wjg.v16.i4.479.

Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia

Imen Sfar  1 , Walid Ben Aleya, Leila Mouelhi, Houda Aouadi, Thouraya Ben Rhomdhane, Mouna Makhlouf, Salwa Ayed-Jendoubi, Houda Gargaoui, Taoufik Najjar, Taieb Ben Abdallah, Khaled Ayed, Yousr Gorgi
Affiliations

Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia

Imen Sfar et al. World J Gastroenterol. .

Abstract

Aim: To assess the possible association between PTPN22 (R620W) gene polymorphism and inflammatory bowel disease (IBD).

Methods: One hundred and sixty-four patients with IBD [105 Crohn's disease (CD) and 59 ulcerative colitis (UC)] and 100 healthy controls were recruited. Genotyping of the PTPN22 gene 1858C-->T polymorphism was performed by restriction fragment length polymorphism-polymerase chain reaction with RsaI digestion.

Results: The genotypic and allelic frequencies of (R620W) PTPN22 gene polymorphism reveal a significant association of the PTPN22 620-W allele with IBD, compared to the healthy control group (OR: 17.81, 95% CI: 4.18-21.86, P = 0.00001). Nevertheless, no difference in this polymorphism was found between CD and UC patients. No significant association was found between the frequencies of genotypes of the PTPN22 gene with either the clinical features such as sex, age, age at disease onset, and extent of colitis, or the production of serological markers (anti-Saccharomyces cerevisiae antibody in CD and perinuclear anti-neutrophil cytoplasmic antibody in UC).

Conclusion: These observations confirm the association of IBD susceptibility with the PTPN22 1858T (620-W) allele in Tunisian patients.

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References

    1. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 1998;115:182–205. - PubMed
    1. Mathew CG, Lewis CM. Genetics of inflammatory bowel disease: progress and prospects. Hum Mol Genet. 2004;13 Spec No 1:R161–R168. - PubMed
    1. Hendrickson BA, Gokhale R, Cho JH. Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev. 2002;15:79–94. - PMC - PubMed
    1. Peeters M, Joossens S, Vermeire S, Vlietinck R, Bossuyt X, Rutgeerts P. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Am J Gastroenterol. 2001;96:730–734. - PubMed
    1. Karlinger K, Györke T, Makö E, Mester A, Tarján Z. The epidemiology and the pathogenesis of inflammatory bowel disease. Eur J Radiol. 2000;35:154–167. - PubMed

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