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Review
. 2010 Jun;10(4):309-15.
doi: 10.1016/j.mito.2010.01.005. Epub 2010 Jan 18.

Autophagy and the degradation of mitochondria

Scott J Goldman  1 , Robert Taylor, Yong Zhang, Shengkan Jin
Affiliations
Review

Autophagy and the degradation of mitochondria

Scott J Goldman et al. Mitochondrion. 2010 Jun.

Abstract

The cellular process of macromolecular degradation known as macroautophagy has long been known to play a role in the elimination of mitochondria. Over the past decade, much progress has been made in the development of systems by which the nature and mechanism of mitochondria degradation may be studied. Recent findings imply that the degradation of mitochondria via autophagy may be more specific and more tightly regulated than originally thought, and have led to designation of this specific type of autophagy as "mitophagy". In this review we provide a brief history of the development of mitophagy models and their associated discoveries.

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Figures

Fig. 1
Fig. 1
Experimental conditions known to trigger mitophagy in yeast and mammals.
Fig. 2
Fig. 2
Mitophagy is critical for normal adipocytes differentiation. Mice with a targeted deletion of the essential autophagy-related gene Atg7 in adipose tissue show increased mitochondria content. LD: lipid droplet; N: nucleus; WAT: white adipose tissue; BAT: brown adipose tissue.
See this image and copyright information in PMC

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References

    1. Abou-Sleiman PM, Muqit MM, McDonald NQ, Yang YX, Gandhi S, Healy DG, Harvey K, Harvey RJ, Deas E, Bhatia K, Quinn N, Lees A, Latchman DS, Wood NW. A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann. Neurol. 2006;60:414–419. - PubMed
    1. Ashford TP, Porter KR. Cytoplasmic components in hepatic cell lysosomes. J. Cell Biol. 1962;12:198–202. - PMC - PubMed
    1. Bassnett S. On the mechanism of organelle degradation in the vertebrate lens. Exp. Eye Res. 2009;88:133–139. - PMC - PubMed
    1. Beaulaton J, Lockshin RA. Ultrastructural study of the normal degeneration of the intersegmental muscles of Antheraea polyphemus and Manduca sexta (Insecta, Lepidoptera) with particular reference of cellular autophagy. J. Morphol. 1977;154:39–57. - PubMed
    1. Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 2006;60:557–569. - PubMed

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