Review
doi: 10.1042/BST0380217.
Regulation of cyclin D1 gene expression
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- PMID: 20074063
- DOI: 10.1042/BST0380217
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Review
Regulation of cyclin D1 gene expression
Biochem Soc Trans.
2010 Feb.
Abstract
Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss the ability of the NF-kappaB (nuclear factor kappaB)/IKK [IkappaB (inhibitor of NF-kappaB) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability.
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