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Review
. 2009 Nov;1(5):a000141.
doi: 10.1101/cshperspect.a000141.

NF-kappaB as a critical link between inflammation and cancer

Michael Karin  1
Affiliations
Review

NF-kappaB as a critical link between inflammation and cancer

Michael Karin. Cold Spring Harb Perspect Biol. 2009 Nov.

Abstract

NF-kappaB transcription factors have been suspected to be involved in cancer development since their discovery because of their kinship with the v-Rel oncogene product. Subsequent work led to identification of oncogenic mutations that result in NF-kappaB activation in lymphoid malignancies, but most of these mutations affect upstream components of NF-kappaB signaling pathways, rather than NF-kappaB family members themselves. NF-kappaB activation has also been observed in many solid tumors, but so far no oncogenic mutations responsible for NF-kappaB activation in carcinomas have been identified. In such cancers, NF-kappaB activation is a result of underlying inflammation or the consequence of formation of an inflammatory microenvironment during malignant progression. Most importantly, through its ability to up-regulate the expression of tumor promoting cytokines, such as IL-6 or TNF-alpha, and survival genes, such as Bcl-X(L), NF-kappaB provides a critical link between inflammation and cancer.

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Figures

Figure 1.
Figure 1.
NF-κB-dependent interactions between myeloid (MØ, DC) and intestinal epithelial cells (IEC) drive the development of colitis-associated cancer.
Figure 2.
Figure 2.
NF-κB in Kupffer cells (KC) and STAT3 in hepatocytes drive the development of DEN-induced hepatocellular carcinoma (HCC).
Figure 3.
Figure 3.
IKKβ–IKKα cross talk drives the development of androgen-independent (AI) prostate carcinoma (CaP).
See this image and copyright information in PMC

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