Aurora kinase inhibitors as anti-cancer therapy
- PMID: 20016367
- DOI: 10.1097/CAD.0b013e3283350dd1
Aurora kinase inhibitors as anti-cancer therapy
Abstract
Aurora kinases are serine and threonine kinases that function as key regulators of the mitosis process. There are three distinct human aurora kinases known as Aurora A, Aurora B, and Aurora C. Aurora A and Aurora B are overexpressed in a number of human cancers including non-small cell lung cancer, glioblastomas, and upper gastrointestinal adenocarcinomas. Given their association with tumorigenesis, both Aurora A and Aurora B have been targeted for cancer therapy. Currently, a number of selective and nonselective aurora kinase inhibitors are being tested in preclinical and clinical settings as anti-tumor agents. We review the biology of human aurora kinases, followed by an overview of inhibitors undergoing current clinical investigations.
Similar articles
-
Aurora kinases: new targets for cancer therapy.Clin Cancer Res. 2006 Dec 1;12(23):6869-75. doi: 10.1158/1078-0432.CCR-06-1405. Clin Cancer Res. 2006. PMID: 17145803 Review.
-
Discovery of a potent and selective aurora kinase inhibitor.Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. doi: 10.1016/j.bmcl.2008.07.073. Epub 2008 Jul 24. Bioorg Med Chem Lett. 2008. PMID: 18678489
-
Danusertib, an aurora kinase inhibitor.Expert Opin Investig Drugs. 2012 Mar;21(3):383-93. doi: 10.1517/13543784.2012.652303. Epub 2012 Jan 13. Expert Opin Investig Drugs. 2012. PMID: 22242557 Review.
-
AT-9283, a small-molecule multi-targeted kinase inhibitor for the potential treatment of cancer.Curr Opin Investig Drugs. 2010 Dec;11(12):1442-9. Curr Opin Investig Drugs. 2010. PMID: 21154126 Review.
-
Development and biological evaluation of a novel aurora A kinase inhibitor.Chembiochem. 2009 Feb 13;10(3):464-78. doi: 10.1002/cbic.200800600. Chembiochem. 2009. PMID: 19199284
Cited by
-
Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells.Drug Des Devel Ther. 2015 Mar 2;9:1293-318. doi: 10.2147/DDDT.S74964. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25767376 Free PMC article.
-
Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1-AKT-p53 Interactions.Cancers (Basel). 2021 May 3;13(9):2195. doi: 10.3390/cancers13092195. Cancers (Basel). 2021. PMID: 34063609 Free PMC article.
-
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy.Med Res Rev. 2019 Jul;39(4):1398-1426. doi: 10.1002/med.21568. Epub 2019 Feb 11. Med Res Rev. 2019. PMID: 30746734 Free PMC article. Review.
-
The potential role of Aurora kinase inhibitors in haematological malignancies.Br J Haematol. 2011 Dec;155(5):561-79. doi: 10.1111/j.1365-2141.2011.08898.x. Epub 2011 Oct 8. Br J Haematol. 2011. PMID: 21980926 Free PMC article. Review.
-
Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells.Int J Mol Sci. 2015 Nov 13;16(11):27228-51. doi: 10.3390/ijms161126018. Int J Mol Sci. 2015. PMID: 26580601 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
