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Review
. 2010;50(1):324-37.
doi: 10.1016/j.advenzreg.2009.12.002. Epub 2009 Dec 16.

Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes

Marco M Tsui  1 , John D York
Affiliations
Review

Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes

Marco M Tsui et al. Adv Enzyme Regul. 2010.
No abstract available

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Figures

FIGURE 1
FIGURE 1. INOSITOL PHOSPHATE AND PYROPHOSPHATE PATHWAYS
Activation of phosphoinositide-specific phospholipase C (PLC) triggers the conversion of phosphatidylinositol 4,5-bisphosphate, PI(4,5)P2, to the second messengers I(1,4,5)P3 and 1,2-diacylglycerol (not shown). Metabolism of I(1,4,5)P3 occurs to generate numerous inositol phosphate and inositol pyrophosphate chemical codes. There are several evolutionarily conserved inositol phosphate kinases that contribute to the production of these regulatory molecules: in mammals there are 6 distinct kinase activities, whereas in the budding yeast there are 4 gene products. The commonly used gene name abbreviations are listed. Inositol phosphatases are omitted for clarity except for the black arrow linking I(1,3,4,5)P4 and I(1,3,4)P3, which is encoded by a 5-phosphatase INPP5.
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