Microbubbles as ultrasound contrast agents and in targeted drug delivery
- PMID: 19961426
- DOI: 10.1615/critrevbiomedeng.v36.i4.10
Microbubbles as ultrasound contrast agents and in targeted drug delivery
Abstract
The development of microbubbles has had considerable impact on the field of diagnostic ultrasound. These minute, gas- or lipid-filled spheres have enabled imaging in the kidney, liver, heart, and myocardium with resolutions that were previously unachievable. Insonation of these microagents generates high-energy cavitational oscillations, which, in addition to providing contrast, can increase local drug diffusivity through microstreaming or bubble collapse. The ability of focused insonation to induce such collapse on ligated microbubbles offers opportunities to deliver targeted therapies in novel ways. Microbubbles have had considerable impact on cancer research in terms of both imagining tumors and through the delivery of therapeutic agents and on the delivery of substances across biological obstructions such as the blood-brain barrier. This review offers a discussion of current approaches used in microbubble construction, of the underlying physics involved in their creation and destruction, and of current applications for these particles, the latter demonstrating their importance for high-contrast medical ultrasound. Challenges to overcome and future areas of microbubble application are also discussed.
Similar articles
-
Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery.Annu Rev Biomed Eng. 2007;9:415-47. doi: 10.1146/annurev.bioeng.8.061505.095852. Annu Rev Biomed Eng. 2007. PMID: 17651012 Review.
-
[Development of Microbubbles for Theranostics and Its Application in Brain Targeted Drug Delivery].Yakugaku Zasshi. 2023;143(10):785-790. doi: 10.1248/yakushi.23-00108. Yakugaku Zasshi. 2023. PMID: 37779005 Japanese.
-
Microbubbles: Revolutionizing Biomedical Applications with Tailored Therapeutic Precision.Curr Pharm Des. 2023;29(44):3532-3545. doi: 10.2174/0113816128282478231219044000. Curr Pharm Des. 2023. PMID: 38151837
-
Ultrasound microbubble contrast agents for diagnostic and therapeutic applications: current status and future design.Chang Gung Med J. 2012 Mar-Apr;35(2):125-39. doi: 10.4103/2319-4170.106159. Chang Gung Med J. 2012. PMID: 22537927 Review.
-
Microbubble Agents: New Directions.Ultrasound Med Biol. 2020 Jun;46(6):1326-1343. doi: 10.1016/j.ultrasmedbio.2020.01.027. Epub 2020 Mar 11. Ultrasound Med Biol. 2020. PMID: 32169397 Review.
Cited by
-
Antibody-based imaging strategies for cancer.Cancer Metastasis Rev. 2014 Sep;33(2-3):809-22. doi: 10.1007/s10555-014-9505-5. Cancer Metastasis Rev. 2014. PMID: 24913898 Free PMC article. Review.
-
Lung surfactant microbubbles increase lipophilic drug payload for ultrasound-targeted delivery.Theranostics. 2013 May 20;3(6):409-19. doi: 10.7150/thno.5616. Print 2013. Theranostics. 2013. PMID: 23781287 Free PMC article.
-
Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors.J Control Release. 2012 Jan 30;157(2):224-34. doi: 10.1016/j.jconrel.2011.09.071. Epub 2011 Sep 17. J Control Release. 2012. PMID: 21945680 Free PMC article.
-
Ultrasound-Triggered Effects of the Microbubbles Coupled to GDNF Plasmid-Loaded PEGylated Liposomes in a Rat Model of Parkinson's Disease.Front Neurosci. 2018 Apr 6;12:222. doi: 10.3389/fnins.2018.00222. eCollection 2018. Front Neurosci. 2018. PMID: 29686604 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
