Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010:658:105-9.
doi: 10.1007/978-1-4419-1050-9_11.

How do bone cells secrete proteins?

Haibo Zhao  1 , Yuji Ito, Jean Chappel, Norma Andrews, F Patrick Ross, Steven L Teitelbaum
Affiliations

How do bone cells secrete proteins?

Haibo Zhao et al. Adv Exp Med Biol. 2010.

Abstract

The ruffled border is the most specific marker of the active osteoclast (OC) as it forms only when the cell is resorbing bone. We provide evidence that this complex cytoskeletal structure reflects insertion of the lysosomal vesicles into the bone-apposed plasma membrane under the aegis of the Ca-sensing, exocytic protein, synaptotagmin VII (SytVII). In the manner, SytVII permits transport of matrix-degrading molecules into the resorptive microenvironment. SytVII also regulates secretion of bone matrix molecules by osteoblasts. Thus, SytVII-deficient mice experience suppressed bone resorption and formation with the latter deficiency predominant thereby yielding osteoporosis characterized by attenuated remodeling.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

LinkOut - more resources