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. 1991 Jan 24;349(6307):329-31.
doi: 10.1038/349329a0.

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

M Bix  1 , N S Liao, M Zijlstra, J Loring, R Jaenisch, D Raulet
Affiliations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

M Bix et al. Nature. .

Abstract

Irradiated MHC-heterozygous mice often reject bone marrow cells transplanted from one of the homozygous parental strains, a phenomenon ('hybrid resistance') that appears to violate the laws of transplantation. Rejection of parental and allogeneic marrow cells also differs from conventional T cell-mediated rejection mechanisms as it is effected by NK1.1+ cells. To account for the unusual specificity of bone marrow rejection, it has been proposed that NK1.1+ cells destroy marrow cells that fail to express the full complement of self MHC class I (MHC-I) molecules. We show here that NK1.1+ cells in normal mice reject haemopoietic transplants from mice that are deficient for normal cell-surface MHC-I expression because of a targeted mutation in the beta 2-microglobulin gene. These findings demonstrate that deficient expression of MHC-I molecules renders marrow cells susceptible to rejection.

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