CONDITIONS DETERMINING THE TRANSPLANTABILITY OF TISSUES IN THE BRAIN
- PMID: 19868782
- PMCID: PMC2128434
- DOI: 10.1084/jem.38.2.183
CONDITIONS DETERMINING THE TRANSPLANTABILITY OF TISSUES IN THE BRAIN
Abstract
In confirmation of Shirai's observation, we find that transplantable mouse tumors grow actively when inoculated into the brains of rats, guinea pigs, and pigeons, whereas subcutaneous or intramuscular grafts in the same animals fail. This growth of foreign tissue in the brain, however, takes place only when the grafted material lies entirely in the brain tissue; if it comes in contact with the ventricle a cellular reaction takes place with resultant destruction of the graft. The growth of foreign tissue in the brain may be completely inhibited by simultaneous inoculations of a small bit of autologous but not by a bit of homologous spleen tissue. Mice highly immune to subcutaneous transplants of mouse cancer show no resistance to such tumors when the inoculation is made into the brain. Although the brain is without obvious power of resistance to implants of transplantable heteroplastic mouse tumors, yet grafts of spontaneous tumors fail to grow there even, as a rule, when tumor implanted and animal host are of the same species.
Similar articles
-
THE BEHAVIOR OF BACILLUS LEPRAE IN COLD-BLOODED ANIMALS.J Exp Med. 1911 May 1;13(5):576-89. doi: 10.1084/jem.13.5.576. J Exp Med. 1911. PMID: 19867440 Free PMC article.
-
FACTORS OF RESISTANCE TO HETEROPLASTIC TISSUE-GRAFTING : STUDIES IN TISSUE SPECIFICITY. III.J Exp Med. 1914 May 1;19(5):513-22. doi: 10.1084/jem.19.5.513. J Exp Med. 1914. PMID: 19867789 Free PMC article.
-
Long-term survival of mouse corpus callosum grafts in neonatal rat recipients, and the effect of host sensitization.J Neurosci Res. 1992 Jan;31(1):33-45. doi: 10.1002/jnr.490310106. J Neurosci Res. 1992. PMID: 1613822
-
Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.Int J Toxicol. 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. Int J Toxicol. 2007. PMID: 17365137 Review.
-
Life history of cells mediating natural resistance to tumor cells and bone-marrow transplants: the respective roles of cell lineage commitment and host environment in determining strain characteristics of natural resistance to foreign marrow grafts.Am J Anat. 1984 Jul;170(3):367-76. doi: 10.1002/aja.1001700311. Am J Anat. 1984. PMID: 6383004 Review.
Cited by
-
CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas.Cancers (Basel). 2016 Jul 27;8(8):71. doi: 10.3390/cancers8080071. Cancers (Basel). 2016. PMID: 27472363 Free PMC article. Review.
-
Introduction to special issue on neuroimmunology in brain development and disease.Dev Neurobiol. 2012 Oct;72(10):1269-71. doi: 10.1002/dneu.22054. Epub 2012 Sep 4. Dev Neurobiol. 2012. PMID: 22927111 Free PMC article. No abstract available.
-
Xenografting of fetal mouse hippocampal tissue to the brain of adult rats: effects of cyclosporin A treatment.Exp Brain Res. 1988;70(1):117-33. doi: 10.1007/BF00271854. Exp Brain Res. 1988. PMID: 3402559
-
Pathophysiology of the blood-brain barrier.Springer Semin Immunopathol. 1996;18(1):57-73. doi: 10.1007/BF00792609. Springer Semin Immunopathol. 1996. PMID: 8984680 Review. No abstract available.
-
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma.Front Oncol. 2021 May 20;11:671044. doi: 10.3389/fonc.2021.671044. eCollection 2021. Front Oncol. 2021. PMID: 34094969 Free PMC article. Review.
