Review
doi: 10.1016/j.febslet.2009.10.053.
Epub 2009 Oct 23.
The KDEL receptor: new functions for an old protein
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- PMID: 19854180
- DOI: 10.1016/j.febslet.2009.10.053
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Review
The KDEL receptor: new functions for an old protein
FEBS Lett.
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Free article
Abstract
The KDEL receptor is a seven-transmembrane-domain protein that was first described about 20 years ago. Its well-known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum. Recent studies, however, have suggested that the KDEL receptor has additional functions. Indeed, we have demonstrated that chaperone-bound KDEL receptor triggers the activation of Src family kinases on the Golgi complex. This activity is essential in the regulation of Golgi-to-plasma membrane transport. However, the identification of different KDEL receptor interactors that are inconsistent with these established functions opens the possibility of further receptor activities.
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