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Review
. 2009 Oct;7(5):297-306.
doi: 10.1016/s1479-666x(09)80008-5.

High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma

S S Liau  1 , E Whang
Affiliations
Review

High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma

S S Liau et al. Surgeon. 2009 Oct.

Abstract

High mobility group A1 (HMGA1) proteins are architectural transcriptional factors that are over-expressed in a wide range of human malignancies. Recently published evidence suggests HMGA1 is a promising candidate biomarker and therapeutic target in pancreatic cancer. This review summarises data implicating HMGA1 as an important mediator of progression in human cancer and in pancreatic cancer.

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Figures

Fig. 1
Fig. 1
Overview of the pancreatic cancer TMA stained with H&E (A) and HMGA1 immunostaining (B). Magnified view (X100) of HMGA1 immunostaining in: (C) normal pancreas (HMGA1-negative), (D) pancreatic adenocarcinoma (HMGA1-negative), (E) Pancreatic adenocarcinoma (HMGA1-positive). F) A high power magnification (X400) of HMGA1-positive cancer section showing intense nuclear staining for HMGA1 G) Survivals of HMGA1-negative patients were compared with HMGA1-positive patients using Kaplan Meier analysis with log-rank test (P=0.0028). Adapted from Liau et al, Cancer 2008;113(2): 302–314, with permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc. Copyright 2008 American Cancer Society.
Fig. 2
Fig. 2
Schematic diagram summarising the roles and mediators of HMGA1 in pancreatic adenocarcinoma
See this image and copyright information in PMC

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