Potential adenovirus-mediated gene therapy of glioma cancer
- PMID: 19784809
- DOI: 10.1007/s10529-009-0132-0
Potential adenovirus-mediated gene therapy of glioma cancer
Abstract
Malignant gliomas are typically characterized by rapid cell proliferation and a marked propensity to invade and damage surrounding tissues. They are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatments. With recent advances in neuroscience and improved understanding of the molecular mechanisms of invasive migration, gene therapy provides a new strategy for treating glioma cancer. Brain tumor gene therapy using viral vectors and stem cells has shown promise in animal model and human patient studies. Here, we review recent studies on engineering adenoviral vectors that can be used as therapy for brain tumors. The new findings presented in this study are essential for the further exploration of this cancer and they represent an approach for developing a newer and more effective therapeutic approach in the clinical treatment of human glioma cancer.
Similar articles
-
Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase.Cancer Res. 2001 Dec 15;61(24):8743-50. Cancer Res. 2001. PMID: 11751394
-
Conditionally replicative adenoviral vectors for malignant glioma.Rev Med Virol. 2006 Mar-Apr;16(2):99-115. doi: 10.1002/rmv.490. Rev Med Virol. 2006. PMID: 16416455 Review.
-
Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.Cancer Res. 2008 Dec 1;68(23):9614-23. doi: 10.1158/0008-5472.CAN-08-0451. Cancer Res. 2008. PMID: 19047138
-
Sequential delivery of interferon-alpha gene and DCs to intracranial gliomas promotes an effective antitumor response.Gene Ther. 2004 Nov;11(21):1551-8. doi: 10.1038/sj.gt.3302300. Gene Ther. 2004. PMID: 15343358
-
[Gene therapy for brain tumors--present conditions and prospects].Gan To Kagaku Ryoho. 2005 Apr;32(4):458-62. Gan To Kagaku Ryoho. 2005. PMID: 15853210 Review. Japanese.
Cited by
-
Role of heat-shock proteins in infection of human adenocarcinoma cell line MCF-7 by tumor-adapted rotavirus isolates.Colomb Med (Cali). 2021 Mar 16;52(1):e2024196. doi: 10.25100/cm.v51i4.4196. Colomb Med (Cali). 2021. PMID: 33911319 Free PMC article.
-
Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs.J Neurooncol. 2012 May;107(3):457-62. doi: 10.1007/s11060-011-0763-6. Epub 2011 Nov 23. J Neurooncol. 2012. PMID: 22108716 Review.
-
Developmental Landscape of Potential Vaccine Candidates Based on Viral Vector for Prophylaxis of COVID-19.Front Mol Biosci. 2021 Apr 15;8:635337. doi: 10.3389/fmolb.2021.635337. eCollection 2021. Front Mol Biosci. 2021. PMID: 33937326 Free PMC article. Review.
-
New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy.Biologics. 2018 Feb 9;12:43-60. doi: 10.2147/BTT.S140114. eCollection 2018. Biologics. 2018. PMID: 29445265 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
