Dynamic regulation of Notch signaling in neural progenitor cells
- PMID: 19783418
- DOI: 10.1016/j.ceb.2009.08.009
Dynamic regulation of Notch signaling in neural progenitor cells
Abstract
In the developing nervous system, differentiating neurons express Delta and activate Notch signaling in their neighboring cells. As a result of Notch activation, neuronal differentiation is inhibited in neighboring cells and they remain neural progenitor cells. Thus, differentiation of neurons and maintenance of neural progenitor cells are well balanced owing to Notch signaling. Recent studies revealed that Notch signaling is under the control of more complex and dynamic regulation than previously thought, such as cell cycle dependent activation and oscillating gene expression. We discuss here recent advances in understanding how Notch signaling is regulated in the developing nervous system and what outcome each type of regulation of Notch signaling leads to. We highlight the role of Notch signaling in proliferation and differentiation of neural progenitor cells.
Similar articles
-
Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes.Development. 2005 Jun;132(12):2759-70. doi: 10.1242/dev.01856. Epub 2005 May 18. Development. 2005. PMID: 15901663
-
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition.Nat Neurosci. 2008 Nov;11(11):1247-51. doi: 10.1038/nn.2208. Nat Neurosci. 2008. PMID: 18956012
-
Notch signaling is required for the maintenance of enteric neural crest progenitors.Development. 2008 Nov;135(21):3555-65. doi: 10.1242/dev.022319. Epub 2008 Oct 2. Development. 2008. PMID: 18832397
-
Strange bedfellows: Reelin and Notch signaling interact to regulate cell migration in the developing neocortex.Neuron. 2008 Oct 23;60(2):189-91. doi: 10.1016/j.neuron.2008.10.009. Neuron. 2008. PMID: 18957210 Review.
-
Notch in the vertebrate nervous system: an old dog with new tricks.Neuron. 2011 Mar 10;69(5):840-55. doi: 10.1016/j.neuron.2011.02.031. Neuron. 2011. PMID: 21382546 Review.
Cited by
-
Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions.Nucleic Acids Res. 2012 Apr;40(7):3218-31. doi: 10.1093/nar/gkr1139. Epub 2011 Dec 2. Nucleic Acids Res. 2012. PMID: 22140116 Free PMC article.
-
Role for Lhx2 in corticogenesis through regulation of progenitor differentiation.Mol Cell Neurosci. 2013 Sep;56:1-9. doi: 10.1016/j.mcn.2013.02.006. Epub 2013 Feb 26. Mol Cell Neurosci. 2013. PMID: 23454273 Free PMC article.
-
Modelling the Delta1/Notch1 pathway: in search of the mediator(s) of neural stem cell differentiation.PLoS One. 2011 Feb 8;6(2):e14668. doi: 10.1371/journal.pone.0014668. PLoS One. 2011. PMID: 21346804 Free PMC article.
-
Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.Neuroscience. 2019 Aug 10;413:230-238. doi: 10.1016/j.neuroscience.2019.05.062. Epub 2019 Jun 14. Neuroscience. 2019. PMID: 31202705 Free PMC article.
-
The role of ubiquitylation in nerve cell development.Nat Rev Neurosci. 2011 May;12(5):251-68. doi: 10.1038/nrn3009. Nat Rev Neurosci. 2011. PMID: 21505515 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
