Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Oct;9(10):691-700.
doi: 10.1038/nrc2715. Epub 2009 Sep 17.

p53 and metabolism

Karen H Vousden  1 , Kevin M Ryan
Affiliations
Review

p53 and metabolism

Karen H Vousden et al. Nat Rev Cancer. 2009 Oct.

Abstract

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 2009 Jan 30;284(5):2803-2810 - PubMed
    1. Science. 2006 Jun 16;312(5780):1650-3 - PubMed
    1. Nat Cell Biol. 2004 Dec;6(12):1221-8 - PubMed
    1. J Carcinog. 2009;8:8 - PubMed
    1. Mol Cell Biol. 2003 Dec;23(23):8576-85 - PubMed

Publication types

Substances

LinkOut - more resources