Review
doi: 10.1158/0008-5472.CAN-08-4041.
Epub 2009 Sep 8.
Advances in Ewing's sarcoma research: where are we now and what lies ahead?
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- PMID: 19738075
- DOI: 10.1158/0008-5472.CAN-08-4041
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Review
Advances in Ewing's sarcoma research: where are we now and what lies ahead?
Cancer Res.
.
Abstract
Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target gene networks within the context of other signaling pathways, together with the identification of the initiating cell, and the development of genetically engineered mice will hopefully lead to biology-based therapeutic strategies for these tumors.
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