An update on community-associated MRSA virulence
- PMID: 19726228
- DOI: 10.1016/j.coph.2009.07.009
An update on community-associated MRSA virulence
Abstract
Staphylococcus aureus is a major health problem worldwide and the leading cause of bacterial infections in the United States. Historically, the success of S. aureus as a human pathogen has been facilitated by a strong propensity to develop antibiotic resistance and multidrug resistant strains are endemic in hospitals. However, one of the most striking developments in recent bacterial infectious disease history was the rapid emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). First reported in the 1990s, CA-MRSA has since emerged worldwide and is epidemic in the United States. The pathogen is characterized by its ability to spread rapidly and cause infections in otherwise healthy individuals. This review focuses on current progress toward understanding the enhanced virulence properties of CA-MRSA, with an emphasis on Panton-Valentine leukocidin, alpha-hemolysin, and the recently discovered alpha-type phenol-soluble modulins.
Similar articles
-
Re: is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?J Infect Dis. 2007 Jun 1;195(11):1726; author reply 1727-8. doi: 10.1086/517528. J Infect Dis. 2007. PMID: 17471445 No abstract available.
-
Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus.Annu Rev Microbiol. 2010;64:143-62. doi: 10.1146/annurev.micro.112408.134309. Annu Rev Microbiol. 2010. PMID: 20825344 Review.
-
Community-acquired methicillin-resistant Staphylococcus aureus: what do we need to know?Clin Microbiol Infect. 2009 Dec;15 Suppl 7:17-25. doi: 10.1111/j.1469-0691.2009.03097.x. Clin Microbiol Infect. 2009. PMID: 19951330 Review.
-
Community-associated Staphylococcus aureus infections in children.Expert Rev Anti Infect Ther. 2010 May;8(5):541-54. doi: 10.1586/eri.10.34. Expert Rev Anti Infect Ther. 2010. PMID: 20455683 Review.
-
Community-associated methicillin-resistant Staphylococcus aureus (MRSA) in Australia.Int J Antimicrob Agents. 2008 May;31(5):401-10. doi: 10.1016/j.ijantimicag.2007.08.011. Epub 2008 Mar 14. Int J Antimicrob Agents. 2008. PMID: 18342492 Review.
Cited by
-
Distinct roles of phenol-soluble modulins in spreading of Staphylococcus aureus on wet surfaces.Appl Environ Microbiol. 2013 Feb;79(3):886-95. doi: 10.1128/AEM.03157-12. Epub 2012 Nov 26. Appl Environ Microbiol. 2013. PMID: 23183971 Free PMC article.
-
Peppermint oil decreases the production of virulence-associated exoproteins by Staphylococcus aureus.Molecules. 2011 Feb 15;16(2):1642-54. doi: 10.3390/molecules16021642. Molecules. 2011. PMID: 21326141 Free PMC article.
-
Current concepts on the virulence mechanisms of meticillin-resistant Staphylococcus aureus.J Med Microbiol. 2012 Sep;61(Pt 9):1179-1193. doi: 10.1099/jmm.0.043513-0. Epub 2012 Jun 28. J Med Microbiol. 2012. PMID: 22745137 Free PMC article. Review.
-
Targeting the host hemostatic system function in bacterial infection for antimicrobial therapies.J Thromb Thrombolysis. 2014 Jan;37(1):66-73. doi: 10.1007/s11239-013-0994-9. J Thromb Thrombolysis. 2014. PMID: 24379143 Review.
-
Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model.PLoS One. 2013;8(4):e60463. doi: 10.1371/journal.pone.0060463. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565251 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
