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. 2009:2009:412908.
doi: 10.1155/2009/412908. Epub 2009 Aug 19.

Biomolecular markers in cancer of the tongue

Daris Ferrari  1 , Carla Codecà, Jessica Fiore, Laura Moneghini, Silvano Bosari, Paolo Foa
Affiliations

Biomolecular markers in cancer of the tongue

Daris Ferrari et al. J Oncol. 2009.

Abstract

The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.

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References

    1. Pimenta Amaral TM, Da Silva F, Carvalho AL, Pinto CAL, Kowalski LP. Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth. Oral Oncology. 2004;40(8):780–786. - PubMed
    1. Kademani D, Bell RB, Bagheri S, et al. Prognostic factors in intraoral squamous cell carcinoma: the influence of histologic grade. Journal of Oral and Maxillofacial Surgery. 2005;63(11):1599–1605. - PubMed
    1. Shantz SP, Harrison LB, Forastiere AA. Tumors of the nasal cavity and paranasal sinuses, nasopharynx, oral cavity, and oropharynx. In: De Vita T, Hellman S, Rosemberg SA, editors. Principles and Practice of Oncology. 7th edition
    1. Byers RM. Squamous cell carcinoma of the oral tongue in patients less than thirty years of age. American Journal of Surgery. 1975;130(4):475–478. - PubMed
    1. Jones JB, Lampe HB, Cheung HW. Carcinoma of the tongue in young patients. Journal of Otolaryngology. 1989;18(3):105–108. - PubMed

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