The physiologic development of fetuin-a serum concentrations in children
- PMID: 19690510
- DOI: 10.1203/PDR.0b013e3181bc3f60
The physiologic development of fetuin-a serum concentrations in children
Abstract
Fetuin-A prevents tissue calcification by forming soluble complexes with calcium and phosphate. A pathological depletion of serum fetuin-A has been observed in children on dialysis or after renal transplantation but knowledge on physiologic age-related changes in serum fetuin-A is limited. We prospectively evaluated serum fetuin-A in 133 infants and children, ranging from very low birth weight infants to adolescents. Highest serum fetuin-A levels were present between 23 and 30 wk of gestation (1 +/- 0.33 mg/mL). Thereafter, the values decreased. This decrease was linked to biological rather than chronological age. At 32 to 36 and 37 to 40 wk of gestation, the serum fetuin-A concentration was 0.63 +/- 0.26 and 0.63 +/- 0.21 mg/mL, respectively. Thereafter, the concentrations remained stable until adolescence at 0.58 +/- 0.12 mg/mL. Intercurrent infections were associated with a transient decrease of serum fetuin-A levels. The high serum fetuin-A concentrations in preterm children suggest that fetuin-A is of high physiologic impact for the fetal and the preterm-born organism, showing extensive tissue formation. This might point to a new mechanism contributing to organ damage in these patients, comparable with children on dialysis.
Similar articles
-
Reduced serum fetuin-A in nephrotic children: a consequence of proteinuria?Am J Nephrol. 2011;34(4):373-80. doi: 10.1159/000331061. Epub 2011 Sep 2. Am J Nephrol. 2011. PMID: 21893974
-
Serum fetuin-A/alpha2-HS-glycoprotein in human pregnancies with normal and restricted fetal growth.J Matern Fetal Neonatal Med. 2008 Nov;21(11):826-30. doi: 10.1080/14767050802326255. J Matern Fetal Neonatal Med. 2008. PMID: 19031279
-
Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients.Nephrol Dial Transplant. 2005 Aug;20(8):1676-85. doi: 10.1093/ndt/gfh891. Epub 2005 May 17. Nephrol Dial Transplant. 2005. PMID: 15899935
-
The role of fetuin-A in physiological and pathological mineralization.Calcif Tissue Int. 2013 Oct;93(4):355-64. doi: 10.1007/s00223-012-9690-6. Epub 2013 Jan 1. Calcif Tissue Int. 2013. PMID: 23277412 Review.
-
Fetuin-A function in systemic mineral metabolism.Trends Cardiovasc Med. 2012 Nov;22(8):197-201. doi: 10.1016/j.tcm.2012.07.020. Epub 2012 Aug 16. Trends Cardiovasc Med. 2012. PMID: 22902178 Review.
Cited by
-
Post-translational modifications glycosylation and phosphorylation of the major hepatic plasma protein fetuin-A are associated with CNS inflammation in children.PLoS One. 2022 Oct 7;17(10):e0268592. doi: 10.1371/journal.pone.0268592. eCollection 2022. PLoS One. 2022. PMID: 36206263 Free PMC article.
-
Mineral and bone disorders in children with chronic kidney disease.Nat Rev Nephrol. 2011 Sep 27;7(11):624-34. doi: 10.1038/nrneph.2011.139. Nat Rev Nephrol. 2011. PMID: 21947120 Review.
-
Uremic Toxins and Vascular Calcification-Missing the Forest for All the Trees.Toxins (Basel). 2020 Sep 29;12(10):624. doi: 10.3390/toxins12100624. Toxins (Basel). 2020. PMID: 33003628 Free PMC article. Review.
-
The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells.Diabetologia. 2021 Jun;64(6):1358-1374. doi: 10.1007/s00125-021-05435-1. Epub 2021 Mar 25. Diabetologia. 2021. PMID: 33765181 Free PMC article.
-
The Effect of Fetuin-A and Other Laboratory Paremeters on Prognosis and Mortality in Crimean-Congo Hemorrhagic Fever.Iran J Public Health. 2023 Jan;52(1):97-105. doi: 10.18502/ijph.v52i1.11670. Iran J Public Health. 2023. PMID: 36824242 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
