Infectivity of blood seropositive for hepatitis C virus antibodies
- PMID: 1968574
- DOI: 10.1016/0140-6736(90)90347-8
Infectivity of blood seropositive for hepatitis C virus antibodies
Abstract
Stored serum samples from 5150 blood product transfusions and 383 recipients were tested for antibodies to hepatitis C virus (anti-HCV) by a recombinant enzyme-linked immunosorbent assay (ELISA) as part of a prospective study on post-transfusion non-A, non-B hepatitis (NANBH). Donor cofactors associated with HCV infectivity of anti-HCV-positive blood products were raised alanine aminotransferase concentrations (6 of 9 infective vs 1 of 26 not infective); a mean ELISA optical density/cut-off ratio greater than or equal to 2 (7 of 9 vs 9 of 26); both preceding factors (together in 6 blood products, all of which transmitted infection); and persistent donor anti-HCV seropositivity. Use of anti-HCV screening to prevent post-transfusion NANBH was compared with measurement of alanine aminotransferase concentrations: a corrected efficacy of 63% and 65%, a specificity of 93% and 64%, and a positive predictive value of 16.2% and 3.6% were found, respectively; 0.7% or 3.8% of blood donations, respectively, would be discarded. Blood donor screening for anti-HCV is recommended to reduce the incidence of post-transfusion NANBH.
Comment in
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Recombinant immunoblot assay for hepatitis C virus antibody as predictor of infectivity.Lancet. 1990 Apr 21;335(8695):982-3. doi: 10.1016/0140-6736(90)91055-f. Lancet. 1990. PMID: 1970062 No abstract available.
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Anti-HCV and transaminase testing of blood donors.Lancet. 1990 Jul 21;336(8708):187-8. Lancet. 1990. PMID: 1973511 No abstract available.
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Is anti-HCV blood donor screening useful?Lancet. 1990 Nov 10;336(8724):1193. doi: 10.1016/0140-6736(90)92809-v. Lancet. 1990. PMID: 1978051 No abstract available.
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