Virus-encoded homologs of cellular interleukin-10 and their control of host immune function

doi:10.1128/JVI.01098-09

Review

. 2009 Oct;83(19):9618-29.

doi: 10.1128/JVI.01098-09. Epub 2009 Jul 29.

Virus-encoded homologs of cellular interleukin-10 and their control of host immune function

Barry Slobedman¹, Peter A Barry, Juliet V Spencer, Selmir Avdic, Allison Abendroth

Affiliations

PMID: 19640997
PMCID: PMC2747999
DOI: 10.1128/JVI.01098-09

Review

Virus-encoded homologs of cellular interleukin-10 and their control of host immune function

Barry Slobedman et al. J Virol. 2009 Oct.

. 2009 Oct;83(19):9618-29.

doi: 10.1128/JVI.01098-09. Epub 2009 Jul 29.

Authors

Barry Slobedman¹, Peter A Barry, Juliet V Spencer, Selmir Avdic, Allison Abendroth

Affiliation

¹ Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Sydney, Australia. barry_slobedman@wmi.usyd.edu.au

PMID: 19640997
PMCID: PMC2747999
DOI: 10.1128/JVI.01098-09

No abstract available

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Figures

**FIG. 1.**
Structure of hIL-10 and vIL-10 homologs bound to the hIL-10R. hIL-10 (A), ebvIL-10 (B), and cmvIL-10 (C) dimers bound to soluble IL-10R1 (sIL-10R1) are shown. The interdomain angles of each IL-10 are shown at the top of each complex. The rotation (in degrees) of each IL-10 domain angle on the surface of sIL-10R1 is denoted by arrows where the movement is from the circle to the arrowhead. For the cmvIL-10/sIL-10R1 complex, the rotation of each sIL-10R1 relative to the hIL-10/sIL-10R1 complex is also shown.

**FIG. 2.**
Alignment of cellular and vIL-10 proteins. Proteins were aligned by the ClustalW method, using the MegAlign software program (Lasergene, DNASTAR). Cellular and vIL-10 host names are shown in italic and bold fonts, respectively. Nucleotide sequence accession numbers for the indicated genera or viruses are as follows: *Ovis* (sheep; GenBank accession number NP_001009327), *Capra* (goat; ABI20513), *Bos* (bovine; NP_776513), ORFV (AAC57332), equine herpesvirus 2 ([EHV2] AAB26148), *Equus* (horse; NP_001075959), *Papio* (baboon; Q5Q0V6), *Macaca* (rhesus macaque [*Macaca mulatta*]; NP_001038192), *Homo sapiens* (human; P22301), macacine herpesvirus 4 [McHV4]/rhesus lymphocryptovirus (AAK95412), EBV/human herpesvirus 4 (P03180), OvHV2 (ABB22222), LSDV (AAN02729), SPPV (NP_659579), GPV (GPV Pellor; YP_001293197), McHV3/RhCMV (AAF59907), African green monkey CMV ([AGMCMV] AAF63435), baboon CMV ([BaCMV] AAF63436), HCMV/human herpesvirus 5 (AAF36285), *Cyprinus* (common carp [*Cyprinus carpio*]; BAC76885), cyprinid herpesvirus 3 ([CyHV3] YP_001096169).

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References

1. Aoki, T., I. Hirono, K. Kurokawa, H. Fukuda, R. Nahary, A. Eldar, A. J. Davison, T. B. Waltzek, H. Bercovier, and R. P. Hedrick. 2007. Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide. J. Virol. 81:5058-5065. - PMC - PubMed
1. Berkman, N., M. John, G. Roesems, P. J. Jose, P. J. Barnes, and K. F. Chung. 1995. Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. J. Immunol. 155:4412-4418. - PubMed
1. Brady, M. T., A. J. MacDonald, A. G. Rowan, and K. H. Mills. 2003. Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur. J. Immunol. 33:3448-3457. - PubMed
1. Brockman, M. A., D. S. Kwon, D. P. Tighe, D. F. Pavlik, P. C. Rosato, J. Sela, F. Porichis, S. Le Gall, M. T. Waring, K. Moss, H. Jessen, F. Pereyra, D. G. Kavanagh, B. D. Walker, and D. E. Kaufmann. 2009. IL-10 is upregulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood 114:346-356. - PMC - PubMed
1. Chan, K. S., and A. Kaur. 2007. Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques. J. Immunol. Methods 325:20-34. - PMC - PubMed

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[1] Aoki, T., I. Hirono, K. Kurokawa, H. Fukuda, R. Nahary, A. Eldar, A. J. Davison, T. B. Waltzek, H. Bercovier, and R. P. Hedrick. 2007. Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide. J. Virol. 81:5058-5065. - PMC - PubMed

[2] Aoki, T., I. Hirono, K. Kurokawa, H. Fukuda, R. Nahary, A. Eldar, A. J. Davison, T. B. Waltzek, H. Bercovier, and R. P. Hedrick. 2007. Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide. J. Virol. 81:5058-5065. - PMC - PubMed

[3] Berkman, N., M. John, G. Roesems, P. J. Jose, P. J. Barnes, and K. F. Chung. 1995. Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. J. Immunol. 155:4412-4418. - PubMed

[4] Berkman, N., M. John, G. Roesems, P. J. Jose, P. J. Barnes, and K. F. Chung. 1995. Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. J. Immunol. 155:4412-4418. - PubMed

[5] Brady, M. T., A. J. MacDonald, A. G. Rowan, and K. H. Mills. 2003. Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur. J. Immunol. 33:3448-3457. - PubMed

[6] Brady, M. T., A. J. MacDonald, A. G. Rowan, and K. H. Mills. 2003. Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur. J. Immunol. 33:3448-3457. - PubMed

[7] Brockman, M. A., D. S. Kwon, D. P. Tighe, D. F. Pavlik, P. C. Rosato, J. Sela, F. Porichis, S. Le Gall, M. T. Waring, K. Moss, H. Jessen, F. Pereyra, D. G. Kavanagh, B. D. Walker, and D. E. Kaufmann. 2009. IL-10 is upregulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood 114:346-356. - PMC - PubMed

[8] Brockman, M. A., D. S. Kwon, D. P. Tighe, D. F. Pavlik, P. C. Rosato, J. Sela, F. Porichis, S. Le Gall, M. T. Waring, K. Moss, H. Jessen, F. Pereyra, D. G. Kavanagh, B. D. Walker, and D. E. Kaufmann. 2009. IL-10 is upregulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood 114:346-356. - PMC - PubMed

[9] Chan, K. S., and A. Kaur. 2007. Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques. J. Immunol. Methods 325:20-34. - PMC - PubMed

[10] Chan, K. S., and A. Kaur. 2007. Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques. J. Immunol. Methods 325:20-34. - PMC - PubMed

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Virus-encoded homologs of cellular interleukin-10 and their control of host immune function

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Virus-encoded homologs of cellular interleukin-10 and their control of host immune function

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