Limb development: the rise and fall of retinoic acid
- PMID: 19640492
- DOI: 10.1016/j.cub.2009.06.017
Limb development: the rise and fall of retinoic acid
Abstract
Retinoic acid was thought to play a key instructive role during limb bud initiation and subsequent patterning. New results argue instead that its role is permissive: retinoic acid is essential only to antagonize early axial Fgf signals that otherwise inhibit the limb field.
Comment on
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Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning.Curr Biol. 2009 Jun 23;19(12):1050-7. doi: 10.1016/j.cub.2009.04.059. Epub 2009 May 21. Curr Biol. 2009. PMID: 19464179 Free PMC article.
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